Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (28): 5165-5169.doi: 10.3969/j.issn.2095-4344.2012.28.008

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Low level laser for repair of collagen in the tendon of rats with enthesiopathy

Shen Yong-wei1, Shi Xiao-wei2   

  1. 1Institute of Physical Education, Soochow University, Suzhou 215021, Jiangsu Province, China;
    2Department of Physical Education, Hainan Normal University, Haikou 570100, Hainan Province, China
  • Received:2011-11-01 Revised:2011-12-17 Online:2012-07-08 Published:2012-07-08
  • About author:Shen Yong-wei☆, Studying for doctorate, Associate professor, Institute of Physical Education, Soochow University, Suzhou 215021, Jiangsu Province, China shenyongwei0719@163.com

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Abstract:

BACKGROUND: Low level laser therapy (LLLT) has the specific stimulation effect on organism (photobiomodulation). In general case, it can produce some biological effects without temperature increase.
OBJECTIVE: To observed the effect of low level laser on contents of hydroxyproline and gene expression of collagenⅠin the tendon of rats with enthesiopathy.
METHODS: Ninety-six male Wistar rats were randomly divided into two groups. The control group was without ant treatment. Rats in the model group were stimulated to the feet with electrostimulating jumping method to build the model of enthesiopathy. Rats in the LLLT group were treated with LLLT to the tendon after model building.
RESULTS AND CONCLUSION: Compared with the control group, the contents of hydroxyproline and gene expression of collagenⅠ in the tendon of rats with enthesiopathy were significantly decreased (P < 0.05). After LLLT, low level laser could increase the contents of hydroxyproline and gene expression of collagen I in the tendon of rats with enthesiopathy, and this started from 7 days and was obviously increased at 14 days. It is indicated that low level laser can improve the contents of hydroxyproline and the metabolism of collagenⅠin the tendon of rats with enthesiopathy, and can promote the healing of tendon in early stage.

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