Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (45): 8487-8490.doi: 10.3969/j.issn.1673-8225.2010.45.030

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Reprogramming of induced pluripotent stem cells

Bian He-tao1, Huang Wei1, Li Shi-yong2   

  1. 1 Department of Neurology, 2 Molecule Center Laboratory, Second Affiliated Hospital, Nanchang University, Nanchang  330006, Jiangxi Province, China 　
  • Online:2010-11-05 Published:2010-11-05
  • Contact: Li Shi-yong, Doctor, Molecule Center Laboratory, Second Affiliated Hospital, Nanchang University, Nanchang 330006, Jiangxi Province, China syliwy@gmail.com
  • About author:Bian He-tao★, Studying for master’s degree, Department of Neurology, Second Affiliated Hospital, Nanchang University, Nanchang 330006, Jiangxi Province, China hetaobian@163.com

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Abstract:

BACKGROUND: Although induced pluripotent stem cells (iPSCs) have similar morphological, epigenetic and gene expression characteristics as embryonic stem cells (ESCs), this research is at a very early stage and many fundamental questions remain such as security and efficiency.
OBJECTIVE: To review empirical study of iPSCs.
METHODS: A computer-based online search of Medline, Ovid, CNKI, and EBSCO databases was undertaken for the literature of iPSCs. The key words were “induced pluripotent stem cells, embryonic stem cells, somatic cells, reprogramming, induction, transcription factor”.
RESULTS AND CONCLUSION: iPSCs of specific genes, mainly through import, reprogram somatic cells. Its specific genes include Oct 4, Sox2, c-Myc, Klf4, Nanog, Lin-28. These exogenous transcription factors can activate endogenous Oct4 and Sox2 expression, which contribute to form a network of self-regulation and to maintain iPSCs pluripotent. However, the specific mechanism of reprogramming remains unclear.

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