Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (40): 7547-7550.doi: 10.3969/j.issn.1673-8225.2010.40.031

Previous Articles     Next Articles

Wnt signaling and differentiation of neural stem cells

Bian He-tao, Huang Wei   

  1. Department of Neurology, Second Affiliated Hospital, Nanchang University, Nanchang  330006, Jiangxi Province, China
  • Online:2010-10-01 Published:2010-10-01
  • Contact: Huang Wei, Associate professor, Master’s supervisor, Department of Neurology, Second Affiliated Hospital, Nanchang University, Nanchang 330006, Jiangxi Province, China huangwei94@tom.com
  • About author:Bian He-tao★, Studying for master’s degree, Department of Neurology, Second Affiliated Hospital, Nanchang University, Nanchang 330006, Jiangxi Province, China hetaobian@163.com

PDF

401

Abstract:

BACKGROUND: Studies have suggested that neural stem cells (NSCs) transplanted in the host can differentiate into neurons or glial cells. Wnt signaling pathway is closely associated with NSC differentiation. The oriented differentiation of NSCs can be controlled by regulating Wnt signaling pathway.
OBJECTIVE: To summarize the relationship of NSC differentiation and Wnt signaling pathway.
METHODS: A computer-based online search of Medline, Ovid, CNKI, and EBSCO databases was undertaken for the literatures of NSCs published from February 2002 to March 2010. The key words were “neural stem cells, neural regeneration, Wnt signaling, neuron, differentiation”. The literatures associated with NSC differentiation and with Wnt signaling system were included, whereas repetitive studies were excluded. A total of 30 remaining literatures were used for review.
RESULTS AND CONCLUSION: NSCs possess the potential of self-renewal and multi-directional differentiation, can differentiate into many types of cells in the central nervous system. Wnt signaling pathway plays an important role in NSC differentiation. This study analyzed NSCs, Wnt signaling pathway, the correlation of Wnt signaling pathway and NSC differentiation. However, precise mechanism of controlling NSC differentiation by Wnt signaling pathway remains unclear.

CLC Number: