Chinese Journal of Tissue Engineering Research ›› 2016, Vol. 20 ›› Issue (48): 7192-7199.doi: 10.3969/j.issn.2095-4344.2016.48.007

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Special formed titanium mesh cages for treating spinal tuberculosis via one-stage posterior approach

Abudunaibi•Aili1, 2, Zhang Hong-qi1, Huang Wei-min2, Li Lei2, Tian Hui-zhong2   

  1. 1Spinal Surgery Center, Xiangya Hospital, Central South University, Changsha 410000, Hunan Province, China; 2Second Department of Spinal Surgery, Sixth Affiliated Hospital, Xinjiang Medical University, Urumqi 830000, Xinjiang Uygur Autonomous Region, China
  • Revised:2016-09-02 Online:2016-11-25 Published:2016-11-25
  • Contact: Zhang Hong-qi, M.D., Chief physician, Spinal Surgery Center, Xiangya Hospital, Central South University, Changsha 410000, Hunan Province, China
  • About author:Abudunaibi?Aili, Studying for doctorate, Attending physician, Spinal Surgery Center, Xiangya Hospital, Central South University, Changsha 410000, Hunan Province, China; Second Department of Spinal Surgery, Sixth Affiliated Hospital, Xinjiang Medical University, Urumqi 830000, Xinjiang Uygur Autonomous Region, China
  • Supported by:

    the General Program of the Natural Science Foundation of Xinjiang Uygur Autonomous Region, No. 2016D01C219

Abstract:

BACKGROUND: How to reconstruct the anterior defect after decomperation for posterior approach is the key of operation. We designed special formed titanium mesh cages matched with one-stage posterior approach surgery. 

OBJECTIVE: To evaluate and observe the clinical feasibility and safety of one-stage posterior internal fixation and interbody fusion with special formed titanium mesh cages in the treatment of spinal tuberculosis.
METHODS: Thirty-two patients with thoracic, lumbar and sacral tuberculosis undergoing special formed titanium mesh cages from July 2009 to June 2011 were enrolled in this study, including 10 cases of thoracic segments, 8 cases of thoracic waist segments (T11-L2), 10 cases of lumbar segments, and 4 cases of lumbar and sacral segments. Changes in neurological function, thoracic and lumbar spinal tuberculosis kyphosis, visual analogue scale score, intervertebral height, lumbosacral angle and erythrocyte sedimentation rate were compared before and after surgery. Operation time, intraoperative blood loss and graft fusion were observed.
RESULTS AND CONCLUSION: (1) Average operation time was 199 minutes; intraoperative blood loss was 520 mL. (2) Postoperative follow-up was 48-72 months. Postoperative neurological function was improved to different degrees. Erythrocyte sedimentation rate recovered to normal 3 months after surgery in 32 patients. During final follow-up, kyphosis angle, lumbosacral angle and the height of intervertebral space were significantly improved (P < 0.001). Visual analogue scale scores decreased 2 weeks after surgery (P=0.001). All patients achieved bone fusion at 7 months averagely after surgery. Superficial wound infection occurred in two cases, and lately healed. No complications, such as tuberculosis, infectious meningitis or titanium mesh subsidence, occurred. (3) These findings confirmed that one-stage posterior internal fixation, debridement and interbody fusion with special formed titanium mesh cages can be a safe effective treatment method with minimal invasion for monosegmental spinal tuberculosis. Moreover, it can improve the stability of the anterior column of the spine. 

中国组织工程研究杂志出版内容重点:人工关节;骨植入物;脊柱骨折;内固定;数字化骨科;组织工程

Key words: Tuberculosis, Spinal, Bone Transplantation, Pain Measurement, Follow-Up Studies, Tissue Engineering

CLC Number: