Effects of short-term high-intensity interval training on ventricular remodeling and mitochondrial content in rats after myocardial infarction

doi:10.3969/j.issn.2095-4344.2016.40.009

Abstract

Abstract:

BACKGROUND: It is unclear whether short-term high-intensity interval training (HIT) can be used to protect against myocardium injury after acute myocardial infarction, as well as the underlying mechanism.

OBJECTIVE: To observe the effects of short-term HIT on the ventricular remodeling and mitochondrial content after acute myocardial infarction, and the biological effect of mitochondrial biogenesis and autophagy in this process.

METHODS: Male Sprague-Dawley rats were modeled into acute myocardial infarction by ligating coronary artery. One week later, HIT was performed: each interval consisted of 4-minute high-intensity running (80% of maximal oxygen consumption) and 3-minute active recovery (40% of maximal oxygen consumption), for 4 consecutive weeks of 5 days each week, repeated 7 cycles.

RESULTS AND CONCLUSION: Four-week HIT after acute myocardial infarction could markedly enhance left ventricular pump function and mitochondrial content, improve mitochondrial membrane potential and ATP synthetic activity, inhibit mitochondrial reactive oxygen species generation, up-regulate PGC-1α/Tfam induced mitochondrial biogenesis and Bnip3/Beclin-1 induced autophagy. These results indicate that short-term HIT can improve normal mitochondrial content after acute myocardial infarction, which in turn ameliorates myocardial systolic property and energy metabolism. As a cardiac rehabilitation method, HIT exhibits fine timeliness.

中国组织工程研究杂志出版内容重点：肾移植；肝移植；移植；心脏移植；组织移植；皮肤移植；皮瓣移植；血管移植；器官移植；组织工程

Key words: Myocardial Infarction, Ventricular Remodeling, Mitochondria, Heart, Exercise Movement Techniques

CLC Number:

R318

He Wei, Li Yu-ming, Zhou Xin, Peng Peng, Qin Yong-sheng, Bo Hai. Effects of short-term high-intensity interval training on ventricular remodeling and mitochondrial content in rats after myocardial infarction[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(40): 5986-5993.

Figures/Tables 2

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