Three-dimensional temperature distribution during femur tumor hyperthermia based on three-dimensional temperature field

doi:10.3969/j.issn.2095-4344.2016.39.016

Abstract

Abstract:

BACKGROUND: Temperature measure methods of human tissue include destructive measurement and nondestructive measurement. Destructive measurement cannot measure three-dimensional (3D) temperature field and nondestructive measure is still in the research stage. It is better way to build a mathematical and physical model to predict and simulate femur tumor hyperthermia.

OBJECTIVE: To obtain the three-dimensional temperature distribution of femur and its surrounding tissues during tumor hyperthermia.

METHODS: 3D temperature distribution was obtained by using finite element method on the basis of heat conduction theory, Laplace equation, Pennes bio-heat transfer equation, thermo physical parameters of bone tissues, the boundary condition, and initial conditions.

RESULTS AND CONCLUSION: The femur had good hinder effect to heat transfer. Femoral temperature curve in the 3D space showed ellipsoid distribution with heat source as the center; the closer from heat source, the greater the temperature gradient was. The three major diameters of temperature isoline were different at 50 ℃, which is maximum in cross section and minimum in the sagittal plane. In the three directions of the femur, transfer capability of temperature was different, so the radius of the inactivation of the tumor was also different. Because the 3D temperature space distribution of femur is asymmetry during hyperthermia, the necessary method is to use more than a heat source in order to avoid residual cancer tissue or destructive normal tissue.

中国组织工程研究杂志出版内容重点：人工关节；骨植入物；脊柱；骨折；内固定；数字化骨科；组织工程

Key words: Femur, Neoplasms, Tissue Engineering

CLC Number:

R318

Gao Su. Three-dimensional temperature distribution during femur tumor hyperthermia based on three-dimensional temperature field[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(39): 5879-5884.

Figures/Tables 2

References

[1] 卫生部统计信息中心.2000年中国卫生统计提要[R].北京:中国卫生部,2000:75-78．
[2] Raut CP,Evans DB,Crane CH,et al.Neoadjuvant therapy for respectable pancreatic cancer.Surg Oncol Clin North Am.2004;13(4):639-661.
[3] Diller J,Lizzi F.Therapeutic application or ultrasound：A review.IEEE EMBS.1987;(4):33．
[4] 周文波,焦富英,赵小青,等.从热疗历史探讨中医治疗肿瘤机理[J].辽宁中医杂志,2005,30(3):187-188.
[5] 王英,胡晓华,黄文成,等.血清恶性肿瘤相关物质群检测在消化系恶性肿瘤热疗治疗中的临床意义[J].检验医学与临床,2009,6(13):1068-1069．
[6] 丁震宇,谢晓东.肿瘤热疗的机制及其临床应用[J].国际肿瘤杂志,2010,37(2):128-130.
[7] Tilly W,Wust P,Rau B,et al.Temperature data and specific absorption rates in pelvic tumors: predictive factors and correlations.Int J Hperthermia.2001;17(2):172-188.
[8] 屠传经,沈珞婵,胡亚才.高温传热学[M].浙江:浙江大学出版社,1997.
[9] Pennes HH.Analysis of tissue and arterial blood temperatures in the resting human forearm.Appl Physiol.1948;1(2):93-122．
[10] 陈卫东,赵成龙.虚拟手术中软组织形变建模及力反馈算法研究[J].中国生物医学工程学报,2014,32(1):114-118．
[11] 尹璐璐,廖琪梅.面部软组织三维有限元模型的建立[J].科学技术与工程,2010,10(12):1671-1815．
[12] Mehrabian H.A constrained reconstruction technique of hyperelasticity parameters for breast cancer assessment.Phys Med Biol.2010;6(55):7489-7508．
[13] Wang HM, Qu SX.Constitutive models of artificial muscles：a review.J Zhejiang University- SCIENCE A.2016;17(1):22-36．
[14] 王沫楠,王树峰,李长青.非均匀各向异性骨建模[J].哈尔滨理工大学学报,2013,18(1):27-31．
[15] Zhong H,Wachowiak MP,Peters TM.A real time finite element based tissue simulation method incorporating nonlinear elastic behavior.Comput Methods Biomech Biomed Engin.2005;8(3):177-189．
[16] Wen Wu, Pheng Ann Heng. An Improved Scheme of an Interactive Finite Element Model for 3D Soft-Tissue Cutting and Deformation.Visual Compute.2005;8(5): 231-256．
[17] Wu W,Sun J, eng PA.A hybrid condensed finite element model for interactive 3D soft tissue cutting.Stud Health Technol Inform.2003;94:401-403．
[18] Biot MA.Theory of elasticity and consolidation for a porous anisotropic solid. J Appl Phys.1955;26(2):182-185.
[19] Bowen RM.Incompressible porous media models by use of the theory of mixtures.Int J Eng Sci.1980; 18(9):1129-1148.
[20] Margareta Nordin,Victor H.Frankel.肌肉骨骼系统基础生物力学[M].邝适存,郭霞译.北京:人民卫生出版社, 2012:22,193,196.
[21] Brolin, K.Cervical Spine Injuries -Numerical Analysis and Statistical Survey. Department of Aeronautics Division of Neuronic Engineering.2002,Royal Institute of Technology: S-100 44Stockholm.
[22] Panjabi MM.Cervical spine models for biomechanical research.Spine.1998;23(24): 2684-2699.
[23] 刘宗亮.中国力学虚拟人颈椎建模与基本问题研究[D].上海:上海交通大学硕士学位论文, 2009:2.
[24] Brekelmans WA,Poort HW,Slooff T.A new method to analyse the mechanical behaviour of skeletal parts. Acta Orthopaedica.1972;43(5):301-317.
[25] Williams JL,Belytschko TB.A three-dimensional model of the human cervical spine for impact simulation.J Biomech Eng.1983;105(4):321-331.
[26] Saito T,Yamamuro T,Shikata J,et al.Analysis and Prevention of Spinal Column Deformity Following Cervical Laminectomy I: Pathogenetic Analysis of Postlaminectomy Deformities.Spine.1991;16(5):494-502.
[27] Teo EC,Paul JP,Evans JH.Finite element stress analysis of a cadaver second cervical vertebra.Med Biol Eng Comput.1994;32(2):236-238.
[28] Yang KH,Zhu F,Luan F,et al.Development of a finite element model of the human neck.Proceeding of the 42nd Stapp Car Crash Conference,1998:111.
[29] Kleinberger M.Application of finite element techniques to the study of cervical spine mechanics. Proceedings of the 37th Stapp car crash conference,USA:SAF International,1993:261-272.
[30] Dauvilliers F,Bendjellal F,Weiss M,et al.Development of a finite element model of the neck.SAE Technical Paper. 1994.
[31] 陈金水,倪斌,陈博,等.寰枢椎脱位三维非线性有限元模型的建立和分析[J].中国脊柱脊髓杂志,2010,20(9):749-753.
[32] 樊继宏,钟世镇,焦培峰,等.以有限元分析为目标的Mimcs颈椎建模的新思路[J].中国临床解剖学杂志,2011,29(2): 222-224.
[33] 柏传毅,宁宁,凌伟,等.C4-C6颈椎有限元模型的建立和多点力学加载方法[J].中国组织工程研究与临床康复,2012, 16(4):585-588.
[34] Zhang H,Bai J.Nonlinear finite element analysis of C0-C1-C2 complex under physiologic loads// Engineering in Medicine and Biology Society, 2005. IEEE-EMBS 2005. 27th Annual International Conference of the.IEEE,2006:6165-6167.
[35] Panzer MB.Numerical Modeling of the Human Cervical Spine in Frontal Impact. Waterloo: University of Waterloo graduate thesis,2006:21,23-24,127.
[36] 段扬,靳安民,张辉,等.下颈椎全椎板切除后不同内固定技术螺钉的应力分布[J].中国脊柱脊髓杂志,2010,20(11): 889-894.
[37] Bozic KJ,Keyak JH,Skinner HB,et al. Three-dimensional finite element modeling of a cervical vertebra: an investigation of burst fracture mechanism.J Spinal Disord.1994;7(2):102-110.
[38] Yoganandan N,Kumaresan S,Voo L,et al.Finite element model of the human lower cervical spine: parametric analysis of the C4-C6 unit.J Biomech Eng. 1997;119(1):87-92.
[39] 王远政,田晓滨,刘洋,等. Mimics及颈椎模型用于下颈椎椎弓根个体化置钉的应用研究[J].第三军医大学学报, 2012, 34(15):1543-1547.
[40] Maas SA,Ellis BJ,Ateshian GA,et al.FEBio: finite elements for biomechanics.J Biomech Eng.2012; 134(1):011005.
[41] Erbulut DU,Zafarparandeh I,Lazoglu I,et al.Application of an asymmetric finite element model of the C2-T1 cervical spine for evaluating the role of soft tissues in stability.Med Eng Phys.2014;36(7):915-921.