Chinese Journal of Tissue Engineering Research ›› 2016, Vol. 20 ›› Issue (26): 3929-3937.doi: 10.3969/j.issn.2095-4344.2016.26.020
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Wang Xin
Revised:
2016-04-12
Online:
2016-06-24
Published:
2016-06-24
About author:
Wang Xin, Attending physician, Department of Orthopedics, Tianjin Port Hospital, Tianjin 300456, China
CLC Number:
Wang Xin . Meta-analysis of death risk factors for hip fracture in the elderly[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(26): 3929-3937.
2.2.3 体质量指数 4篇文献记录了身体质量指数与老年髋部骨折死亡之间的相关性[7-8,24-25],Stata 11.0软件固定效应模型分析4篇研究文献,结果显示各研究间无异质性(P=0.096,I2=49.2),体质量指数为老年髋骨骨折死亡的危险因素(OR=1.20,95%CI:0.84-1.55),见图4。 2.2.4 美国麻醉师协会评分高(American society of Aanesthesiologists,ASA)5篇文献记录了美国麻醉师协会评分与老年髋部骨折死亡之间的相关性[4,7,11,26-27],Stata 11.0软件固定效应模型分析5篇研究文献,结果显示各研究间无异质性(P=0.585,I2=0.0%),美国麻醉师协会评分高为老年髋骨骨折死亡的危险因素(OR=2.25,95%CI:2.11-2.38),见图5。 2.2.5 骨折到手术延迟时间 3篇文献记录了骨折到手术延迟时间与老年髋部骨折死亡之间的相关性[7,20,28],Stata 11.0软件固定效应模型分析3篇研究文献,结果显示各研究间无异质性(P=0.118,I2=48.9%),骨折到手术延迟时间为老年髋骨骨折死亡的危险因素(OR=1.27,95%CI:0.65-1.89),见图6。 2.2.6 骨折前日常生活能力差 4篇文献记录了骨折前日常生活能力差与老年髋部骨折死亡之间的相关性[8,19,21,25],Stata 11.0软件固定效应模型分析4篇研究文献,结果显示各研究间无异质性(P=0.145,I2=44.3%),骨折前日常生活能力差为老年髋骨骨折死亡的危险因素(OR=1.46,95%CI:0.62-2.30),见图7。2.2.7 骨折类型 4篇文献记录了骨折类型与老年髋部骨折死亡之间的相关性[7,15,22,29],Stata 11.0软件固定效应模型分析4篇研究文献,结果显示各研究间无异质性(P=0.382,I2=2.1%),骨折类型为老年髋骨骨折死亡的危险因素(OR=1.52,95%CI:1.15-1.89),见图8。"
2.2.8 骨折前慢性病 心血管疾病:8篇文献记录了骨折前心血管疾病与老年髋部骨折死亡之间的相关性[7-8,10,19-20,30-32],Stata 11.0软件固定效应模型分析8篇研究文献,结果显示各研究间无异质性(P=0.735,I2=0.0%),骨折前心血管疾病为老年髋骨骨折死亡的危险因素(OR=1.46,95%CI:1.23-1.68),见图9。 慢性肺病:5篇文献记录了骨折前慢性肺病与老年髋部骨折死亡之间的相关性[14,19-20,30,33],Stata 11.0软件固定效应模型分析5篇研究文献,结果显示各研究间无异质性(P=0.100,I2=43.6%),骨折前慢性肺病为老年髋骨骨折死亡的危险因素(OR=2.27,95%CI:1.37-3.17),见图10。 痴呆:3篇文献记录了骨折前痴呆与老年髋部骨折死亡之间的相关性[7,10,21],Stata 11.0软件固定效应模型分析3篇研究文献,结果显示各研究间无异质性(P=0.176,I2=42.4%),骨折前痴呆为老年髋骨骨折死亡的危险因素(OR=1.79,95%CI:1.12-2.46),见图11。 2.3 发表偏倚的评估 应用Stata 11.0对每个纳入的文献进行发表偏倚分析,得到的漏斗图整体未出现明显的不对称(漏斗图未显示)。Stata 11.0软件Begg’s线性回归结果显示,除骨折前心血管疾病危险因素对应的文献存在发表偏倚外(P值为0.002,P < 0.05),男性、年龄、体质量指数、美国麻醉师协会评分高、骨折到手术延迟时间、骨折前日常生活能力差、骨折类型、骨折前肺病和骨折前痴呆危险因素对应的文献都不存在发表偏倚(P值分别为0.732、0.113、0.462、0.133、0.734、0.308、0.734、0.133和1.000,P均> 0.05)。"
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