Osteoporosis-related factors in patients with knee osteoarthritis before total knee arthroplasty

doi:10.3969/j.issn.2095-4344.2016.22.003

Abstract

Abstract:

BACKGROUND: The greatest risk of osteoporosis in total knee arthroplasty is perioperative and long-term periprosthetic fractures. However, limited by the traditional concept of osteoarthritis patients who usually not associated with osteoporosis, domestic clinical trials have not given enough attention to the osteoporosis before total knee arthroplasty.

OBJECTIVE: To analyze the osteoporosis and its relative factors in osteoarthritis patients before total knee arthroplasty.

METHODS: Data of 81 cases (81 knees) of knee osteoarthritis who underwent total knee arthroplasty in the Department of Joint Surgery of Tianjin People’s Hospital from January 2012 to November 2014 were retrospectively analyzed. They received lumbar spine and hip bone mineral density examination before surgery. The correlation of bone mineral density with age, body mass index, knee motion range, and knee deformity was analyzed before surgery. The independent risk factors for osteoporosis before replacement were analyzed.

RESULTS AND CONCLUSION: (1) Of 81 patients, there were normal bone mineral density in 25 cases (31%), osteopenia in 35 cases (43%), and osteoporosis in 21 cases (26%). All 10 males had no osteoporosis and 21 in 71 female cases suffered osteoporosis (30%). The incidence of osteoporosis in females was significantly higher than in male patients (P=0.046). (2) There was a linear correlation of bone mineral density with age and body mass index (correlation coefficient r=-0.230, 0.225). (3) The age of ≥ 65 years and body mass index ≥ 25 kg/m² were independent risk factors of osteoporosis before replacement (P < 0.05). (4) Patients with knee osteoarthritis had higher incidence of osteopenia and osteoporosis before total knee arthroplasty. The degree of osteoporosis was negatively correlated with age, but positively correlated with body mass index. The age of ≥ 65 years and body mass index < 25 kg/m² were independent risk factors for preoperative osteoporosis. Thus, bone mineral density examination is essential for those patients before total knee arthroplasty.

中国组织工程研究杂志出版内容重点：人工关节；骨植入物；脊柱；骨折；内固定；数字化骨科；组织工程

Key words: Arthroplasty, Replacement, Knee, Osteoarthritis, Bone Density, Osteoporosis, Tissue Engineering

CLC Number:

R318

Ren Zhi-shuai, Cheng Zhao-jun, Sun He-jun, Sun Zhen-hui, Cui Zi-jian, Zhang Li-long, Lin Yong-zhi, Zhang Ren-zan, Peng Bing, Zhang Xue-li. Osteoporosis-related factors in patients with knee osteoarthritis before total knee arthroplasty[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(22): 3212-3218.

Figures/Tables 5

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