Abstract:

BACKGROUND: The hemodialysis treatment for severe pancreatitis patients can effectively remove all kinds of toxic substances, but it is unclear whether there are differences in the removal effects of different dialysis membrane materials.
OBJECTIVE: To explore the clinical application value of hemodialysis membrane materials in the treatment of severe pancreatitis.
METHODS: Totally 67 patients with severe pancreatitis were enrolled, including 38 males and 29 females, aged 34-81 years, and all underwent continuous bedside hemodialysis within 72 hours of onset. Among them, 32 patients selected polysulfone membrane, and the other 35 patients selected cellulose acetate membrane. Dialysis was done 5 hours once, three times a week. All the patients in these two groups were subjected to stable dialysis for 3 weeks. After 3 weeks, the recovery time required for the levels of serum amylase and white blood cell count in the two groups, treatment efficiency, liver and kidney clinical indicators and levels of inflammatory cytokines were observed and detected.
RESULTS AND CONCLUSION: There were no significant differences in the recovery time required for serum amylase and white blood cell count, the incidence of adverse reactions and the effective rate of treatment between polysulfone membrane and cellulose acetate membrane groups. The acute physiology and chronic health scores, the levels of serum creatinine, triglycerides, blood amylase, alanine aminotransferase, interleukin-6, C-reactive protein and tumor necrosis factor-α after treatment in these two groups were significantly lower than those before treatment (P < 0.05). The blood O2 pressure was significantly higher than that before treatment (P < 0.05), but there were no significant differences in the above indicators between these two groups. These results demonstrate that the dialysis effects of polysulfone and cellulose acetate membranes are equivalent, both of which can effectively remove the harmful toxins in the body.