Chinese Journal of Tissue Engineering Research ›› 2016, Vol. 20 ›› Issue (3): 330-335.doi: 10.3969/j.issn.2095-4344.2016.03.005

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Degradation performance of the digital coralline hydroxyapatite artificial bone scaffold in vitro

Lin Shan1, Huang Xiao-mei2, 3, Rui Gang1, Yin Qing-shui4    

  1. 1Department of Orthopedics, the First Affiliated Hospital of Xiamen University, Xiamen 361003, Fujian Province, China; 2Department of Food and Biological Engineering, Zhangzhou Institute of Technology, Zhangzhou 363000, Fujian Province, China; 3Research Center of Urban Ecological Health and Environmental Safety, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, Fujian Province, China; 4Orthopedic Trauma Center of PLA, Guangzhou General Hospital of Guangzhou Military Region, Guangzhou 510010, Guangdong Province, China
  • Received:2015-10-26 Online:2016-01-15 Published:2016-01-15
  • Contact: Lin Shan, Department of Orthopedics, the First Affiliated Hospital of Xiamen University, Xiamen 361003, Fujian Province, China
  • About author:Lin Shan, M.D., Attending physician, Department of Orthopedics, the First Affiliated Hospital of Xiamen University, Xiamen 361003, Fujian Province, China
  • Supported by:

    the Science and Technology Project of Fujian Provincial Department of Education of China, No. JA12416; the Youth Innovation Project of Natural Science Foundation of Fujian Province, China, No. 2013D013; School-Level Research Project of Zhangzhou Institute of Technology, No. ZZY1204

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Abstract:

BACKGROUND: We have successfully prepared the digital coralline hydroxyapatite artificial bone scaffold in previous experiments, and it has good physicochemical properties and biocompatibility.
OBJECTIVE: To evaluate the in vitro degradation performance of the digital coralline hydroxyapatite artificial bone.
METHODS: We used the mixtures of coralline hydroxyapatite and L-polylactic acid at the mass ratio of 3:1 and 4:1 as raw materials to prepare the digital coralline hydroxyapatite artificial bone scafflold specimens, and then they were immersed in the 50 mL stimulated body fluid with the initial pH value of 7.4 in an incubator at 37 ℃ for degradation. After 16 weeks of degradation, the pH value, calcium and phosphate ion concentration, degradation rate, compressive strength and changes of microstructure were dynamically observed.
RESULTS AND CONCLUSION: At the 16th weeks of degradation, the pH values in the two kinds of digital artificial bone groups maintained at 7.34-7.36, which were higher than that in the L-polylactic acid group (P < 0.01), and lower than that in the coralline hydroxyapatite group (P < 0.01). The calcium ion concentrations in the two kinds of digital artificial bone groups were higher than that in the coralline hydroxyapatite group (P < 0.01), and the phosphorus ion concentrations were lower than that in the coralline hydroxyapatite group (P < 0.01). The degradation rates in the two kinds of digital artificial bone groups were lower than that in the coralline hydroxyapatite group (P < 0.01), and higher than that in the L-polylactic acid group (P < 0.01). The order of the compressive strength was as follows: coralline hydroxyapatite group > 3:1 digital artificial bone group > L-polylactic acid group > 4:1 digital artificial bone group. The cellular structure, porosity and pore size in the two kinds of digital artificial bone groups were all increased. These results show that the prepared digital coralline hydroxyapatite artificial bone scaffold has good degradation propertyies.