Chinese Journal of Tissue Engineering Research ›› 2016, Vol. 20 ›› Issue (3): 324-329.doi: 10.3969/j.issn.2095-4344.2016.03.004

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Wisker-covered porous calcium phosphate ceramics in repair of canine femoral condyle defects

Zhou Chao-xi1, Cui Xu2, Ao Guo-kun2, Xu Tao-tao3, Weng Jie3, Xiao Zhan-wen4, Zhang Xing-dong4, Zhang Cong2   

  1. 1Hebei North University, Zhangjiakou 075000, Hebei Province, China; 2the 309th Hospital of Chinese PLA, Beijing 100091, China; 3the Key Laboratory of Advanced Technology for Materials of Ministry of Education, School of Materials, Southwest Jiaotong University, Chengdu 610000, Sichuan Province, China; 4Engineering Research Center in Biomaterials, Sichuan University, Chengdu 610000, Sichuan Province, China
  • Received:2015-11-24 Online:2016-01-15 Published:2016-01-15
  • Contact: Zhang Cong, Chief physician, the 309th Hospital of Chinese PLA, Beijing 100091, China
  • About author:Zhou Chao-xi, Studying for master’s degree, Hebei North University, Zhangjiakou 075000, Hebei Province, China
  • Supported by:

    the National Natural Science Foundation of China, No. 81190131; the National Key Technology Support Program, No.2012BAI17B01

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Abstract:

BACKGROUND: Previous studies have demonstrated that the internal microstructure of porous calcium phosphate ceramics after the whiskering process has some changes, and obtain good mechanical properties.
OBJECTIVE: To further investigate the effect of whisker-covered porous calcium phosphate ceramics in repair of canine femoral condyle defects.
METHODS: Highly interconnected porous calcium phosphate ceramics was prepared by placeholder method. The whiskering of the materials was finished by hydrothermal process. Fifteen healthy adult beagle dogs were selected in this study. A 10 mm×10 mm cylindrical inclusive bone defect was made bilaterally on the lateral femoral condyle with a drill. The porous calcium phosphate ceramics after the whiskering process was implanted onto the right femoral condyle as experiment group. The porous calcium phosphate ceramics without the whiskering process was implanted onto the left femoral condyle as control group. At 2, 4, 8, and 12 weeks after implantation, X-ray and dual-energy X-ray test were conducted in the bone defect area respectively.
RESULTS AND CONCLUSION: (1) X-ray: With the increase of time, the interface between bone defect and normal bone of two groups gradually blurred, disappeared, and completely fused at 12 weeks. The material in the control group was partially dissolved, while there was no obvious dissolution in the experiment group. No significant difference in the X-ray scores was found between two groups at different time points. (2) Dual-energy X-ray: With the increase of time, the bone mineral density of the two groups both increased gradually, but there was no significant difference in the bone mineral density at different time points between these two groups. These results demonstrate that the porous calcium phosphate ceramics after the whiskering process has good ability to repair the defects of femoral condyle.