Diabetic microangiopathy and peripheral blood neutrophil count

doi:10.3969/j.issn.2095-4344.2015.11.028

Abstract

Abstract:

BACKGROUND: Course of diabetes and hypertension are independent risk factors for diabetic microvascular complications, and fasting C-peptide level is a protective factor. There are many studies concerning glycated hemoglobin, C-reactive protein, white blood cell count and diabetic microvascular complications, but studies about neutrophils are rarely reported.

OBJECTIVE: To investigate the relationship of peripheral blood neutrophil count with diabetic microvascular complications.

METHODS: Totally 112 patients with type 2 diabetes mellitus were selected and divided into two groups according to the presence or absence of microvascular complications: diabetes group and diabetes+ microvascular complication group. The gender, age, ethnic group, disease history and laboratory examination parameters were collected and analyzed with univariate analysis and multivariate analysis.

RESULTS AND CONCLUSION: (1) Univariate analysis: Patients in the diabetes+microvascular complication group had significantly higher age, course of diabetes, globulin, creatinine, the percentage of neutrophile granulocytes, nertrophil count, rate of hypertension than those in the diabetes group (P < 0.05), while the lymphocyte percentage, glomerular filtration rate, and triglyceride level were significantly lower than those in the diabetes group (P < 0.05).
(2) Logistic regression analysis showed that age, course of diabetes and nertrophil count were the independent risk factors of microvascular complications in patients with type 2 diabetes mellitus (odds ratio=1.155, 2.145, 2.275, all P < 0.01). Based on the adjustment of the age factor, the partial correlation analysis showed that the nertrophil count was positively correlated to the levels of creatinine, low-density lipoprotein cholesterol, globulin and hemoglobin, but negatively correlated to the levels of serum bile acid and glomerular filtration rate. Chronic subclinical inflammations are closely correlated to the occurrence of microvascular complication in patients with type 2 diabetes mellitus, and peripheral blood neutrophil count can be used as a predictor of microvascular complication in patients with type 2 diabetes mellitus.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

全文链接：

Key words: Diabetes Mellitus, Type 2, Diabetic Angiopathies, Diabetes Complications

CLC Number:

R318

Wang Jing, He Fang-ping, Na Li-ma, Yilihamujiang Yimamu. Diabetic microangiopathy and peripheral blood neutrophil count [J]. Chinese Journal of Tissue Engineering Research, 2015, 19(11): 1793-1797.

Figures/Tables 3

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