Chinese Journal of Tissue Engineering Research ›› 2014, Vol. 18 ›› Issue (48): 7769-7774.doi: 10.3969/j.issn.2095-4344.2014.48.011

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Analgesic effect of ropivacaine complex liquid injection around the wound in lumbar fusion surgery

Wang Shi-jun1, Li Yu-ting2, Li Chun-de1, Liu Xian-yi1, Sun Hao-lin1, Wang Tian-long2   

  1. 1Department of Orthopedics, Peking University First Hospital, Beijing 100034, China; 2Department of Anesthesiology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China
  • Received:2014-10-23 Online:2014-11-26 Published:2014-11-26
  • Contact: Li Chun-de, Doctoral supervisor, Chief physician, Department of Orthopedics, Peking University First Hospital, Beijing 100034, China
  • About author:Wang Shi-jun, M.D., Attending physician, Department of Orthopedics, Peking University First Hospital, Beijing 100034, China

Abstract:

BACKGROUND: Wound infusions with local anaesthesia have been used as postoperative multimode analgesia following surgery, but there is no clinical study to evaluate the effectiveness of local injection of ropivacaine complex liquid around the wound after lumbar fusion surgery.
OBJECTIVE: To evaluate the analgesic effect of wound infiltration by ropivacaine on postoperative pain after lumbar fusion surgery.
METHODS: 90 patients with lumbar spinal stenosis undergoing lumbar fusion surgery and pedicle screw
internal fixation were randomly divided into two groups: experimental group and control group. The experimental group was treated with intravenous postoperative self-control analgesia and intraoperative infiltration with ropivacaine. The control group was only treated with intravenous postoperative self-control analgesia. The outcomes were evaluated with visual analog scale at 2, 4, 8, 12, 24, and 48 hours after surgery, the total frequency with which patients pushed the button of the patient-controlled analgesia system and the total fentanyl consumption were observed. In addition the incidences of postoperative nausea and vomiting after surgery were compared.
RESULTS AND CONCLUSION: The visual analog scale score at 2, 4, 8, 12, 24 hours after surgery was significantly lower in the experimental group compared with the control group (P < 0.05). Total fentanyl consumption and the total frequency with which patients pushed the button were also significantly lower in the experimental group compared with the control group (P < 0.001). There was no statistically significant difference in the incidences of nausea and vomiting between the two groups (P > 0.05). Intraoperative infiltration with ropivacaine complex liquid during lumbar fusion surgery reduces the severity of postoperative pain and the consumption of opioid.


中国组织工程研究杂志出版内容重点:人工关节;骨植入物;脊柱骨折;内固定;数字化骨科;组织工程


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Key words: lumber vertebra, spinal stenosis, internal fixators, pain management

CLC Number: