Iodine-125 radioactive seed implantation combined with vertebroplasty and nail-rod fixation for thoracolumbar metastatic tumors

doi:10.3969/j.issn.2095-4344.2014.26.019

Abstract

Abstract:

BACKGROUND: At present, vertebroplasty and spinal canal decompression are common methods for treatment of metastatic spinal tumors. Iodine-125 (¹²⁵I) radioactive seed implantation has been shown to control the tumor. However, there were few clinical studies on combined therapy using above-mentioned methods.
OBJECTIVE: To compare the differences of ¹²⁵I radioactive seed implantation combined with vertebroplasty and titanium alloy nail-rod fixation and vertebroplasty combined with titanium alloy nail-rod fixation for treating thoracolumbar metastases on pain control, general performance and improvement of the spinal cord function, and to evaluate clinical value of ¹²⁵I radioactive seed implantation combined with therapeutic plans.
METHODS: Thoracolumbar metastases patients undergoing titanium alloy nail-rod fixation were selected in the Department of Spinal Surgery, Shenzhen Municipal People’s Hospital in China from October 2009 to March 2013. They were assigned to experimental and control groups according to with or without ¹²⁵I radioactive seed implantation. Improvement in neurological function was observed before and 2 weeks, 1, 6, and 12 months after titanium alloy nail-rod fixation in both groups.
RESULTS AND CONCLUSION: All patients were followed up for 7 to 29 months, averagely 15.8 months. There was no loosening of titanium alloy nail-rod fixation and the position of bone cement was good. No seed migration or radioactive spinal cord injury was observed. No relapse or diffusion in the surgical site was observed during follow up. Visual Analogue Scale and Karnofsky Performance Status scores were higher in the experimental group than in the control group (P < 0.05). Frankel level was obviously improved after fixation in both groups compared with preoperation. No significant difference in the improvement of neurological function was detected between the two groups (P > 0.05). Results indicated that ¹²⁵I radioactive seed implantation combined with vertebroplasty and titanium alloy nail-rod fixation for treatment of metastatic spinal tumors showed obvious outcomes in relieving cancer pain.

中国组织工程研究杂志出版内容重点：人工关节；骨植入物；脊柱；骨折；内固定；数字化骨科；组织工程

全文链接：

Key words: bone neoplasms, bradioisotopesb vertebroplasty, pain

CLC Number:

R318

Liu Jun-liang, Gao Guo-yong, Zhen Wan-xin, Liu Yang, Yang Da-zhi, Lin Er-hu. Iodine-125 radioactive seed implantation combined with vertebroplasty and nail-rod fixation for thoracolumbar metastatic tumors[J]. Chinese Journal of Tissue Engineering Research, 2014, 18(26): 4200-4205.

Figures/Tables 5

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