Dialysis time and influencing factor in chronic renal allograft dysfunction patients

doi:10.3969/j.issn.2095-4344.2013.53.009

Abstract

Abstract:

BACKGROUND: Patients with chronic renal allograft dysfunction need dialysis to maintain their survivals and even re-transplantation. However, there is little evidence addressing the time for the initiation of dialysis in patients with chronic renal allograft dysfunction.
OBJECTIVE: To discuss the timing of beginning dialysis and the factors that might contribute to dialysis in chronic renal allograft dysfunction patients.
METHODS: A retrospective study was performed in clinical data of 98 chronic renal allograft dysfunction patients which were recruited from Shanghai Changzheng Hospital from July 2005 to December 2012. The clinical data included creatinine clearance, serum creatinine concentration, symptoms of uremia and comorbidity. Factors that might affect the timing of dialysis were further analyzed.
RESULTS AND CONCLUSION: 86.73% of the patients experienced nausea or vomiting before dialysis, 77.55% occurred with cardiac morbidity and/or neuropathy, and 31.63% needed urgent hemodialysis. Among the 98 patients, the mean creatinine clearance at the time for initiation of hemodialysis was (5.94±063) mL/min, the initial mean creatinine clearance was > 10 mL/min in 9 patients, 5-10 mL/min in 51 patients, and < 5 mL/min in 38 patients. Hepatitis C virus infection patients had higher initial creatinine clearance than non-infected patients(P < 0.05). Experimental findings suggest that, chronic renal allograft dysfunction patients have obvious uremia complications at the beginning of dialysis, the timing for dialysis is late, especially in hepatitis C virus infection patients. Health education and medical care of chronic kidney disease are key factors that affect the timing of dialysis.

中国组织工程研究杂志出版内容重点：肾移植；肝移植；移植；心脏移植；组织移植；皮肤移植；皮瓣移植；血管移植；器官移植；组织工程

全文链接：

CLC Number:

R318

Zuo Fu-jie, Feng Xiao-fang, Min Min, Zhou Mei-sheng, Wang Li-ming. Dialysis time and influencing factor in chronic renal allograft dysfunction patients[J]. Chinese Journal of Tissue Engineering Research, 2013, 17(53): 9151-9156.

Figures/Tables 4

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