Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (43): 8078-8082.doi: 10.3969/j.issn.2095-4344.2012.43.021

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Electrophysiological changes following transplantation of tissue engineered myocardial tissue constructed by the compound of myocardial cells and collagen materials in rats with myocardial infarction

Sun Juan1, Chen Xiao-yang2, Zhang Ling1, Huang Yan3   

  1. 1First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China
    2People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, Xinjiang Uygur Autonomous Region, China
    3Huadong Hospital Affiliated to Fudan University, Shanghai 200040, China
  • Received:2012-01-21 Revised:2012-03-15 Online:2012-10-21 Published:2012-10-21
  • Contact: Huang Yan, Doctor, Associate professor, Associate chief physician, Huadong Hospital Affiliated to Fudan University, Shanghai 200040, China yhuang_look@126.com
  • About author:Sun Juan☆, Doctor, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China sunjuandee@ 126.com Chen Xiao-yang, Attending physician, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, Xinjiang Uygur Autonomous Region, China ShouWANGZHE2046@sina.com

Abstract:

BACKGROUND: Transplantation of tissue engineered myocardial tissue can repair myocardial infarction in rats.
OBJECTIVE: To study the electrophysiological characteristics after the transplantation of tissue engineered myocardial tissue.
METHODS: Thirty SD rats were evenly divided into three groups: control group, model group and transplantation group. A rat model of myocardial infarction was established in the latter two groups. The control group underwent thoracotomy with no ligation of the coronary artery. The transplantation group was transplanted with the compound of myocardial cells and collagen materials after modeled. Amplitude, activation-recovery interval and activation-conduction duration at local myocardium were recorded with microeletrode arrays technique.
RESULTS AND CONCLUSION: ①Compared with the model group, the stationary field amplitude of ventricular myocardium in infarction zone, opposite zone and border zone in the transplantation group were significantly increased (P < 0.05). ②Activation-recovery interval in the model group, as well as infarction zone and infarcted border zone in the transplantation group were prolonged variously (P < 0.05). While the activation-conduction duration of infarction zone, opposite zone and border zone in the transplantation group were shorten compared with the model group. ③In terms of the activation-conduction duration of left ventricular anterior wall, the transplantation group was higher than the control group, but lower than the model group (P < 0.05). These findings suggest that the compound of myocardial cells and collagen materials transplanted can improve the contractile function of the ventricular muscle and electrical conduction time, as well as repair the heart partly.

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