Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (43): 8071-8077.doi: 10.3969/j.issn.2095-4344.2012.43.020

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Absorbable magnesium alloy stents in the coronary artery

Wang Ping1, Lei Li-cheng1, Wang Li-li1, Wang Ru-peng1, Chen Li-li1, Cui Yu-xia1, Liu Yan1, Wang Shuang1, Yang Nuo1, Xu Gui-yu1, Zhao Nan-nan1, Chang Hong2, Gao Li3, Wang Er-de4, Wu Kun4, Cui Fu-zhai5, Yang Jing-qing5, Zhu Jin-wen5, Yang Shui-xiang1   

  1. 1Department of Cardiology, 2Department of Pathology, 3Animal Rooms, Affiliated Beijing Shijitan Hospital of Capital Medical University, Beijing 100084, China; 4Department of Materials, Harbin Institute of Technology, Harbin 150006, Heilongjiang Province, China; 5Department of Materials, Tsinghua University, Beijing 100084, China
  • Received:2012-01-07 Revised:2012-02-20 Online:2012-10-21 Published:2012-10-21
  • Contact: Yang Shui-xiang, Doctor, Chief physician, Professor, Department of Cardiology, Affiliated Beijing Shijitan Hospital of Capital Medical University, Beijing 100084, China sxyang68@163.com
  • About author:Wang Ping☆, Doctor, Attending physician, Department of Cardiology, Affiliated Beijing Shijitan Hospital of Capital Medical University, Beijing 100084, China

Abstract:

BACKGROUND: At present, the subacute thrombosis and restenosis cannot be fundamentally resolved by the local drug-eluting stent which is based on cobalt-chromium alloy in the coronary artery. Therefore, the bio-absorbable stents have become the focus.
OBJECTIVE: To evaluate the biocompatibility, effectiveness and safety of absorbable magnesium alloy stents in the coronary artery.
METHODS: Totally 35 immunized hybrid dogs were all implanted an absorbable magnesium alloy stent in the coronary artery and/or the femoral artery. Each dog received the coronary and femoral angiography after implantation for 24 hours, 3 days, 5 days, 1 week, 2 weeks, 3 weeks and 4 weeks respectively. And then the stent arteries were isolated for histopathological analysis and computer image analysis, besides, the elastic lamina area, lumen area, and the percentage of intimal hyperplasia area were measured.
RESULTS AND CONCLUSION:
Fifty-one stents were implanted in 35 dog’s coronary and femoral arteries successfully. The angiography of the coronary and femoral arteries at different time points after implantation was found the clear lumen, as well as no constriction and thrombosis; besides, the stent was completely degraded at 1 week after implantation. The results of histopathological analysis showed that there was a slight intimal hyperplasia at week 2 after implantation, and the percentage of hyperplasia area was increased with time. These findings suggest that the absorbable magnesium alloy stent in the coronary artery can be degraded within 1 week, and no significant inflammatory response and thrombosis formation were found, what’s more, restenosis degree was slight. Therefore, this kind of stent has good biocompatibility, effectiveness and safet

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