Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (42): 7940-7944.doi: 10.3969/j.issn.2095-4344.2012.42.029

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Lycium barbarum polysaccharides intervene nuclear factor kappa B expression in the submandibular gland tissue of diabetic rats

Zhu Jian-hua1, Li Jia-yi1, Li Wei-shan1, Liu Ji-guang2, Xiao Zhen1   

  1. 1School of Stomatology, Jiamusi University, Jiamusi 154004, Heilongjiang Province, China
    2Jiamusi University, Jiamusi 154007, Heilongjiang Province, China
  • Received:2012-01-17 Revised:2012-02-27 Online:2012-10-14 Published:2012-10-14
  • Contact: Liu Ji-guang, Doctor, Professor, Jiamusi University, Jiamusi 154007, Heilongjiang Province, China
  • About author:Zhu Jian-hua, Professor, School of Stomatology, Jiamusi University, Jiamusi 154004, Heilongjiang Province, China Hailiuxing6@163.com

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Abstract:

BACKGROUND: Nuclear factor-κB is a nuclear transcription factor in a variety of cells, which can mediate transcriptional expression of various inflammatory transmitters and participate in the regulation of apoptosis.
OBJECTIVE: To observe the influence of Lycium barbarum polysaccharides (LBP) on the expression of nuclear factor-κB in the submandibular gland tissue of diabetic rats.
METHODS: Sixty Wistar rats were randomly divided into control, diabetes, LBP groups. Diabetic rat models were induced by alloxan in the latter two groups. After modeling, 50% LBP solution was intragastrically injected into the LBP group, and normal saline with the same volume was injected into the control and diabetes groups. The administration lasted for 8 weeks.
RESULTS AND CONCLUSION: After 8 weeks, the body mass of rats in the diabetes and LBP group was less than that in the control group (P < 0.05), and the rats in the LBP had a higher body mass as compared with those in the diabetes group (P < 0.05). The blood glucose in the diabetes and LBP group was higher than that in the control group (P < 0.05), while the blood glucose was lower in the LBP group compared with the diabetes goriup (P < 0.05). Expression of nuclear factor-κB was not found or little in the normal submandibular gland, but increased in the submandibular gland of diabetic rats and then decreased significantly after LBP treatment. These findings indicate that LBP can inhibit nuclear factor-κB activation and expression, and play a protective role in the submandibular gland tissue of diabetic rats.

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