Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (38): 7101-7106.doi: 10.3969/j.issn.2095-4344.2012.38.015

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Biocompatibility of AZ31 magnesium alloy treated with micro-arc oxidation

Wang Shu-feng1, Li Chun-rong2, Wang Cheng-yue3, Li Shu-hua4, Tan Li-li5, Yang Ke5   

  1. 1Graduate School of Liaoning Medical University, Jinzhou 121000, Liaoning Province, China
    2Depatment of Stomatology, Yumin People’s Hospital, Yumin 834800, Xinjiang Uyghur Autonomous Region, China
    3the Fifth Clinical Hospital of Liaoning Medical University, Jinzhou 121000, Liaoning Province, China
    4the Immune and Microbiology Laboratory of Liaoning Medical University, Jinzhou 121000, Liaoning Province, China
    5Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, Liaoning Province, China
  • Received:2012-01-04 Revised:2012-02-11 Online:2012-09-16 Published:2012-09-16
  • Contact: Wang Cheng-yue, Doctor, Master’s supervisor, the Fifth Clinical Hospital of Liaoning Medical University, Jinzhou 121000, Liaoning Province, China wchy1758@ sohu.com
  • About author:Wang Shu-feng, Physician, Graduate School of Liaoning Medical University, Jinzhou 121000, Liaoning Province, China wsf_20052005@ 163.com

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Abstract:

BACKGROUND: Surface modification and the alteration of alloying components will affect the biocompatibility of magnesium alloy.
OBJECTIVE: To evaluate the biocompatibility of AZ31 magnesium alloy treated with micro-arc oxidation.
METHODS: The passage 3 rabbit bone marrow stroma cells (BMSCs) cultured and expanded in vitro were collected. The cells were implanted into the un-treated AZ31 magnesium alloy (magnesium alloy+BMSCs group) and AZ31 magnesium alloy treated with micro-arc oxidation (magnesium alloy treated with micro-arc oxidation+BMSCs group). In addition, BMSCs were as the blank control group (BMSCs group). Cellular morphology, cell growth and adhesion conditions as well as material surface appearance were observed after cultured for 1, 3, 5 and 7 days.
RESULTS AND CONCLUSION: The cellular morphology in each group was the same, and mainly showed fusiformis. The cell growth condition of the magnesium alloy+BMSCs group was significantly not better than that of magnesium alloy treated with micro-arc oxidation+BMSCs group and BMSCs group (P < 0.05). A large number of cells that grew normally were found adhesion in the material surface of the magnesium alloy treated with micro-arc oxidation+BMSCs group. There were no cells adhered onto the material surface and obvious cracks were seen in the magnesium alloy+BMSCs group. These findings suggest that AZ31 magnesium alloy treated with micro-arc oxidation has good biocompatibility, which is helpful to cell adhesion and normal growth.

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