Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (37): 7003-7008.doi: 10.3969/j.issn.2095-4344.2012.37.032

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Costimulatory effect of mechanical stress and body stress on beta-catenin and bone metabolism in the phosphoinositide 3 kinase/protein kinase signal pathway

Bao Jie1, 2, Wang Guo-xiang1   

  1. 1Physical Education School of Soochow University, Suzhou 215021, Jiangsu Province, China
    2Jie Mei Biomedicine Engineering Instrument Joint Core Laboratory, Suzhou 215006, Jiangsu Province, China
  • Received:2011-11-22 Revised:2012-01-29 Online:2012-09-09 Published:2012-09-09
  • Contact: Wang Guo-xiang, Professor, Doctoral supervisor, Physical Education School of Soochow University, Suzhou 215021, Jiangsu Province, China kwang63@163.com
  • About author:Bao Jie☆, Studying for doctorate, Lecturer, Physical Education School of Soochow University, Suzhu 215021, Jiangsu Province, China; Jie Mei Biomedicine Engineering Instrument Joint Core Laboratory, Suzhou 215021, Jiangsu Province, China baojie@suda.edu.cn

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Abstract:

BACKGROUND: Exercising mechanical stress affect the body with the body stress. Wnt/β-catenin signal pathway is the most classic signal in the Wnt signal family with the mechanical stress sensitivity. It could change the mechanics signal into biochemistry signal, through making the cyclooxy enase-2/prostaglandin E-2 (COX-2/PGE-2) signal as a medium to accommodate downstream osteoprotegerin receptor activator of nuclear factor-κB ligand, receptor activator of nuclear factor κB (OPG/RANKL/RANK) signal and influence bone metabolism. Interleukin-6 is a signal pathway which transfers the message through the Janus kinase/signal transduction and activation of transcription (JAK/STAT) and influences bone metabolism.
OBJECTIVE: To explore the costimulatiory effect of mechanical stress and body stress on β-catenin whether is in the same signal pathway.
METHODS: An online search of CNKI, HighWire and Elsevier databases was performed for articles related to “mechanical stress, body stress, wnt/β-catenin, PI3K/Akt, bone metabolism”. Articles published from 2000 to 2011 and related to the effects of mechanical stress and body stress on the signaling pathways were selected. A total of 37 articles were included.
RESULTS AND CONCLUSION: As a medium of wnt/β-catenin signal way with the mechanical stress sensitivity, COX-2/PGE-2 cooperated with the Interleukin-6 produced by body stress to amplify the β-catenin signal through activating phosphoinositide 3 kinase /protein kinase (PI3K/Akt) signal pathway, and strengthen the regulatory effect of OPG/RANKL/RANK bone receiving signal pathway. These could explain the mechanism of susceptibility bone injury caused by excessive training and verify the costimulatory effect of mechanical stress and body stress on β-catenin in the signal pathway.

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