Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (36): 6795-6799.doi: 10.3969/j.issn.2095-4344.2012.36.026

Previous Articles     Next Articles

Effects of mechanical factors on osteogenic differentiation of mesenchymal stem cells

Lü Zhen-jing, Li Zhi-zhong   

  1. Department of Orthopedics, Guangzhou Overseas Chinese Hospital, First Affiliated Hospital of Jinan University, Guangzhou 510632, Guangdong Province, China
  • Received:2011-12-24 Revised:2012-03-24 Online:2012-09-02 Published:2012-09-02
  • Contact: Li Zhi-zhong, M.D., Professor, Doctoral supervisor, Department of Orthopedics, Guangzhou Overseas Chinese Hospital, First Affiliated Hospital of Jinan University, Guangzhou 510632, Guangdong Province, China
  • About author:Lü Zhen-jing★, Studying for master’s degree, Department of Orthopedics, Guangzhou Overseas Chinese Hospital, First Affiliated Hospital of Jinan University, Guangzhou 510632, Guangdong Province, China Zhenjing0411@163.com

PDF

338

Abstract:

BACKGROUND: With wide study of mesenchymal stem cells, the osteogenic differentiation of mesenchymal stem cells has been fully confirmed. Recently, many scholars are studying the effects of mechanical factors on osteogenic differentiation of mesenchymal stem cells.
OBJECTIVE: To review the effects of mechanical factors on osteogenic differentiation of mesenchymal stem cells.
METHODS: A computer-based online retrieval of PubMed, ScienceDirect, ISI-SCIE, Chinese Journal Full-text Database, China Journal Full-text Database (Century Journals Project), China Doctor Dissertations Full-text Database, China Master's Theses Full-text Database for searching papers describing the effects of mechanical factors on osteogenic differentiation of mesenchymal stem cells published between January 1999 and December 2012 using the key words “mechanical factors, mesenchymal stem cell, osteogenic differentiation” in English and Chinese. The papers published recently or in high-impact journals were selected. A total of 104 papers were initially selected, and 30 were included in the final analysis.
RESULTS AND CONCLUSION: Mechanical factors play an important role in proliferation, differentiation, morphology, development and function of mesenchymal stem cells. Mechanical stimulations at different intensities, modes and for different time produce different effects on directed differentiation and function of mesenchymal stem cells. The optimal mechanical stimulation promoted the osteogenic differentiation of mesenchymal stem cells, thereby achieving the optimal clinical therapeutic effects.

CLC Number: