Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (33): 6081-6086.doi: 10.3969/j.issn.2095-4344.2012.33.001

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Early joint activities effect on the tendon-to-bone healing after anterior cruciate ligamen reconstruction in a rabbit model

Chen Bo-jian1, Liu Jun1, Xu Shu-chai1, Wang Sheng-xian2   

  1. 1Department of Orthopedics Ershadao Branch, Guangdong Provincial Traditional Chinese Medicine Hospital, Guangzhou 510120, Guangdong Province, China;
    Department of Orthopedics, Yantai Harbor Hospital, Yantai 264002, Shandong Province， China
  • Received:2012-03-14 Revised:2012-05-05 Online:2012-08-12 Published:2012-08-12
  • Contact: Liu Jun, Doctor, Chief physician, Doctoral supervisor, Department of Orthopedics Ershadao Branch, Guangdong Provincial Traditional Chinese Medicine Hospital, Guangzhou 510120, Guangdong Province, China liujun.tcm@163.com
  • About author:Chen Bo-jian★, Master, Attending physician, Department of Orthopedics Ershadao Branch, Guangdong Provincial Traditional Chinese Medicine Hospital, Guangzhou 510120, Guangdong Province, China 13538796124@139.com

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Abstract:

BACKGROUND: Allograft can be used as the selection for anterior cruciate ligament reconstruction and the repair of knee joint compound injury. .
OBJECTIVE: To investigate the effects of early activities on the tissue morphology of tendon-to-bone healing of allograft and the recovery of joint function via the establishment of ligament allograft transplantation of anterior cruciate ligament reconstruction in a rabbit model.
METHODS: Nine healthy adult New Zealand rabbits were selected. Three of them were collected and their bilateral achilles tendons served as donors. Then, six rabbits were collected and their one side of the anterior cruciate ligament of knee joints was cut off. Next, the anterior cruciate ligament was reconstructed. After that the anterior cruciate ligament was randomized into activity group and inactivity group. Finally, joint function and tendon-to-bone healing were observed by gross and histological observation at week 6 after surgery.
RESULTS AND CONCLUSION: The results of observation showed that surgical limb activities were normal, and all rabbits’ anterior cruciate ligament end points were healed well; the synovium around the anterior cruciate ligament were found obviously hyperplasy. Besides, More Sharpey fibers were observed in the activity group. Moreover, tendon bone formed and connected indirectly. While obvious Sharpey fibers were not seen in the inactivity group. These findings suggest that at week 6 after surgery, tendon-to-bone healing was found after allograft reconstruction. Early activities not only have no significant adverse effects on tendon-to-bone healing after anterior cruciate ligament reconstruction, but also may be more favorable.

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