Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (31): 5761-5764.doi: 10.3969/j.issn.1673-8225.2011.31.014

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Gene expression detection in kidney tissue allograft transplantation for improvement of renal anemia

Liu Rong-yao, Liu Bai-cheng, Wang Wang-long, Zhang Hong-yu, Guo Jian-zhong, Liu Jing   

  1. Department of Urinary Surgery, Lüliang Municipal People’s Hospital, Lüliang  033000, Shanxi Province, China
  • Received:2011-01-30 Revised:2011-05-28 Online:2011-07-30 Published:2011-07-30
  • About author:Liu Rong-yao★, Master, Associate chief physician, Department of Urinary Surgery, Lüliang Municipal People’s Hospital, Lüliang 033000, Shanxi Province, China lry186@sohu.com
  • Supported by:

    Youth Foundation Program of Shanxi Province, No. 2010021036-5

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Abstract:

BACKGROUND: Erythropoietin (EPO) deficiency is difficult to improve renal anemia caused by chronic renal failure.
OBJECTIVE: To investigate the effects of kidney tissue allograft transplantation on EPO gene expression in rats with renal anemia.
METHODS: A total of 80 Wistar rats were randomly divided into four groups: normal control, case control, recombinant human EPO, and kidney tissue allograft. Rats in the kidney tissue graft group were developed into models of renal failure.
RESULTS AND CONCLUSION: At 60 days after renal transplantation, hemoglobin level and serum level of EPO were significantly higher in the kidney tissue allograft group than in the case control group (P < 0.05), and there were no significant difference in these two indices between the kidney tissue allograft group and recombinant human EPO group (P > 0.05). EPO mRNA expression was significantly higher in the kidney tissue allograft group than in the case control group (P< 0.05). These findings suggest that the mechanism underlying kidney tissue allograft for improvement is that increased EPO mRNA expression in the kidney tissue increases EPO expression in the kidney and thereby increases hemoglobin level.

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