Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (30): 5556-5560.doi: 10.3969/j.issn.1673-8225.2011.30.012

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Effects of bridge combined fixation system on healing of fractures in dogs 

Xiong Ying, Lu Ji-peng, Li Qun-hui, Zhao Feng, Zhang Wu    

  1. Department of Orthopedics, Kunming Yan’an Hospital Affiliated to Kunming Medical University, Kunming  650051, Yunnan Province, China
  • Received:2011-01-31 Revised:2011-03-29 Online:2011-07-23 Published:2011-07-23
  • Contact: Lu Ji-peng, Master, Attending physician, Department of Orthopedics, Kunming Yan’an Hospital Affiliated to Kunming Medical University, Kunming 650051, Yunnan Province, China lujipeng_km@yahoo.com.cn
  • About author:Xiong Ying, Chief physician, Department of Orthopedics, Kunming Yan’an Hospital Affiliated to Kunming Medical University, Kunming 650051, Yunnan Province, China
  • Supported by:

    the Scientific Research Fund of Yunnan Provincial Education Bureau, No. 08C0113*

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Abstract:

BACKGROUND: In recent years, studies concerning internal fixation mainly emphasize on reducing stress-shielding effect and damage to blood supply.
OBJECTIVE: To investigate the influence and mechanism of bridge combined fixation system (BCFs) on fracture healing.
METHODS: Bilateral tibia of 20 adult dogs were osteotomized in the middle and fixed with BCFs (experimental group) on left or right side at random, another side fixed with plate (control group). Five animals in each group were sacrificed at 4, 8, 12, 16 weeks after operation and observed with pathological examination, X-ray examination, and light microscopy.
RESULTS AND CONCLUSION: In the control group, fracture splitting, loose steel plate and steel fracture were found separately in one case at 3 weeks. While in the experimental group, flexural deformation was found in one case at 5 weeks. Callus could be observed with X-ray in the experimental group at 8 weeks, which was earlier than the control group. The X-ray grade of the experimental group were higher than that of the control group every period, and there were significant difference at 16 weeks (P <  0.05). Light microscopy showed that the quantity and quality of fibroblast, capillary vessel and callus of the experimental group were better than those of the control group. The hematoxylin-eosin stained grade of experimental group were higher than control group every period, there were prominent difference at 8 and 16 weeks (P  < 0.05). BCFs not only reduce the breakage of vessels near fracture part, but also afford firm and dynamic fixation for fracture fragment, which enhances healing and bone reconstruction.

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