Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (30): 5511-5515.doi: 10.3969/j.issn.1673-8225.2011.30.001

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A receptor pathway via the lumbar intervertebral disc

Geng Zhu-sheng1, 2, Zhang Yun-hai1, 2, Lei Ling1, Cui Ji-zheng1, 2, Zhang Xiao-bao1, Yang Cong-ying3, Li Yu4, Xu Xin-tang5   

  1. 1Department of Anesthesiology, 2Department of Pain, 3Department of Pathology, 5Department of Radiology, First People’s Hospital of Lianyungang City, Lianyungang  222002, Jiangsu Province, China; 4Lianyungang Clinical Laboratory Center, Lianyungang  222002, Jiangsu Province, China
  • Received:2011-05-24 Revised:2011-06-30 Online:2011-07-23 Published:2011-07-23
  • Contact: Zhang Yun-hai, Chief physician, Department of Anesthesiology, First People’s Hospital of Lianyungang City, Lianyungang 222002, Jiangsu Province, China zyh1957423@sina.com
  • About author:Geng Zhu-sheng, Associate chief physician, Department of Anesthesiology, First People’s Hospital of Lianyungang City, Lianyungang 222002, Jiangsu Province, China Gengzs1898@sina.com
  • Supported by:

    国家自然科学基金(30271260)：皮内注射局麻药远程镇痛机制的研究；江苏高校省级重点实验室第三批对外开放课题(K2093)：皮内给药镇痛机制的研究；江苏省科技厅指导计划课题(BS2002305)：皮内感受器通路与中医经络相关的神经基础研究；连云港市科技局课题(SH0408)：皮内注药治疗带状疱疹后遗神经痛机制研究；连云港市科技局课题(SH0507)：与胃牵涉区相关的皮部腧穴通路的研究；连云港市科技局课题(SH0905)：经腰椎关节突和椎板骨骼肌附着点感受器通路形态学研究。

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Abstract:

BACKGROUND: Which skeletal muscle labeled peripheral neurons at attachment points of the lumbar facet and lamina can enter the disc? The receptor pathway via the lumbar intervertebral disc is unclear.
OBJECTIVE: To observe the morphologic characteristics of the receptor pathway via the lumbar intervertebral disc.
METHODS: Injection of fluorescent retrograde nerve tracer into the L3-4 segments of eight rabbits was performed for retrograde nerve tracing. The rabbits were divided into two groups: one group at 18 hours after injection, and the other group at 36 hours after injection. Consecutive frozen sections from different zones were taken for observation of nerve end, and the exposure time was recorded.
REUSLTS AND CONCLUSION: Receptor pathway network of the lumbar intervertebral disc in rabbits was composed of sympathetic ganglia and postganglionic neurons, intestinal ganglion cells, and spinal ganglion. Targeted sites were lumbar disc annulus, lumbar intervertebral disc nucleus, lumbar synovial membrane, gastric mucosa, intestinal mucosa, fascia, etc., overlapped with the receptor pathway at the sympathetic ganglia and postganglionic neurons, intestinal ganglion cells, spinal ganglia. Disc administration can cause inflammatory reactions of many spinal ganglia.

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