Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (29): 5453-5458.doi: 10.3969/j.issn.1673-8225.2011.29.033

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Biofilm on the surface of polymers

Li Hong-mei1, Ji Jun-hui2   

  1. 1Department of Respiratory Medicine, the 309 Hospital of Chinese PLA, Beijing  100091, China
    2National Engineering Research Center of Plastics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing  100190, China
  • Received:2011-01-09 Revised:2011-02-11 Online:2011-07-16 Published:2011-07-16
  • Contact: Ji Jun-hui, Doctor, Investigator, Doctoral supervisor, National Engineering Research Center of Plastics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China
  • About author:Li Hong-mei☆, Doctor, Associate chief Physician, Department of Respiratory Medicine, the 309 Hospital of Chinese PLA, Beijing 100091, China lihongmei309@163.com
  • Supported by:

    the Key Science and Technology Program of Zhejiang Province, No. 2005C21064*; the Science and Technology Program for Disability of Knowledge Innovation Project, Chinese Academy of Sciences, No. KGCX2-YW-608*

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Abstract:

BACKGROUND: Widely application of medical devices, especially application of polymeric catheters and tubes is one of the important approaches which lead to catheter-related infection. Biofilm which formed on the surface of the polymeric medical devices in the application process is just the reason for this nosocomial infection.
OBJECTIVE: To review the formation procedures of biofilm and the factors influencing the formation and progression of biofilm, as well as common methods to inhibit biofilm formation.
METHODS: With key words “mycoderm, biomembrane, biofilm”; “polymer, plastics, rubber” in Chinese and English, a computer-based online search of medline, life sciences, Toxline plus, Derwent drug file, CBMDisc, and CMCC, as well as www.ncbi.nlm.nih.gov, www.uspto.gov, www.patent.com.cn, was performed. A total of 214 articles were collected, and 43 were included after eliminating repetitive and similar articles.
RERULTS AND CONCLUSION: Formation procedure and mechanism of biofilm on the surface of polymeric devices have been expounded clearly, but researches on biofilm mainly focus on microbiology, medicine or gene, and antibiotics for the prevention and treatment of biofilm. This paper reviewed the effects of matrix material on the inhibiting of formation biofilm and possibility to use in clinic.

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