Abstract:

BACKGROUND: With the popularity of minimally invasive techniques in recent years, tubal recanalization treatment for tubal obstruction has been more common, but postoperative adhesion is still a great trouble for clinicians.
OBJECTIVE:To review the application status of chitosan gel in the treatment of adhesion following tubal recanalization.
METHODS: The first author retrieved related articles about application of chitosan gel against postoperative adhesion following tubal recanalization published from 1998-02 to 2011-02 using the keywords of “chitosan gel; laparoscopy; treatment; tubal pregnancy”. Repetitive or old articles were excluded, and finally 30 relevant papers were included.
RESULTS AND CONCLUSION: Chitosan is a medical polymer polysaccharide with good biocompatibility, biodegradability and biological activity. With broad-spectrum antimicrobial effect, chitosan selectively promotes the growth of epithelial cells and endothelial cells, and inhibits fibroblast growth, thereby contributing to physiological tissue repair and rapid wound healing, inhibiting scar formation, and reducing tissue adhesion. Because of lubrication and biological barrier effects, chitosan can effectively prevent adhesion occurrence and promote functional recovery of the oviduct to lay the foundation for the subsequent pregnancy.