Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (29): 5379-5383.doi: 10.3969/j.issn.1673-8225.2011.29.015

Previous Articles     Next Articles

Mesoporous silicon dioxide microsphere/starch composite hemostatic dressing

Wang Li-qun1, Xu Lei2, Wang Shu-wei3, Su Jia-can4   

  1. 1Department of Gynecology and Obstetrics, Tangshan Worker’s Hospital, Tangshan  063000, Hebei Province, China; 2Department of Chinese and Western Medicine, Ninth Hospital of Tangshan, Tangshan  063000, Hebei Province, China; 3Department of Respiratory Medicine, Tangshan Worker’s Hospital, Tangshan  063000, Hebei Province, China; 4Department of Orthopedics, Changhai Hospital, Second Military Medical University of Chinese PLA, Shanghai  200433, China
  • Received:2011-03-30 Revised:2011-06-01 Online:2011-07-16 Published:2011-07-16
  • Contact: Su Jia-can, Doctor, Associate chief physician, Associate professor, Department of Orthopedics, Changhai Hospital, Second Military Medical University of Chinese PLA, Shanghai 200433, China sujiacan@yahoo.com.cn
  • About author:Wang Li-qun, Associate chief physician, Department of Gynecology and Obstetrics, Tangshan Worker’s Hospital, Tangshan 063000, Hebei Province, China ttyuli26@126.com
  • Supported by:

    the Project of Science and Technology Research & Development of Tangshan, No. 05134609a*; the Talent Development Fund of Shanghai Personnel Bureau, No. 2009003*; Shanghai Postdoctoral Fund, No. 11R21412700*; General Program of China Postdoctoral Science Foundation, No. 20100470756*

PDF

475

Abstract:

BACKGROUND: Wound bleeding is an important part of traumatism first aid.
OBJECTIVE: To develop a novel mesoporous silicon dioxide microsphere/starch composite hemostatic dressing and to study its hemostatic properties.
METHODS: A hemostatic dressing of mesoporous silicon dioxide microsphere/starch composite was synthesized by using pluronic (P123) as templates and sol-gel process, and its hemostatic properties were also investigated. The mesoporous silicon dioxide microsphere had large surface area and pore diameter of around 5 nm.
RESULTS AND CONCLUSION: The mesoporous silicon dioxide microsphere/starch composite had good water adsorption properties as compared with mesoporous silicon dioxide and silicon dioxide (S). The mesoporous silicon dioxide microsphere/starch composite could significantly short the partial thromboplastin time and prothrombin time. The mesoporous silicon dioxide microsphere/starch composite could shorten the bleeding time of skin and liver wound of rabbits, and control hemorrhage, showing good hemostatic properties.

CLC Number: