Abstract:

BACKGROUND: Development of tissue engineering can realize the repair of nerve defects. Combination of stem cells and nerve guide conduit scaffold is the core to construct tissue-engineered nerves.
OBJECTIVE: To investigate how to better repair nerve defects based on tissue-engineering application of stem cells and construction of nerve conduit scaffolds with good biocompatibility.
METHODS: CNKI and Medline databases were searched for articles addressing stem cells from different sources and nerve conduit scaffolds for repair of nerve defects published from 1996-01 to 2011-01. The keywords were “stem cells, nerve damage, repair, nerve guide conduit, nerve scaffold materials” in Chinese and “stem cells, nerve damage, repair, nerve guide conduit material, scaffold materials, nerve tissue engineering” in English. Repetitive studies or Metal analysis were excluded, and finally 30 articles were included.
RESULTS AND CONCLUSION: The transplanted neural stem cell can survive, proliferate and migrate in the nervous system, and can be differentiated into corresponding cells at different regions, which brings a new hope for nerve repair. In addition, with the development of biomaterials, nerve conduit materials have also made excellent results in the repair of nerve defects, and have a good prospect. Neural stem cells combined with biodegradable nerve conduit materials are expected to better meet the requirements of nerve scaffolds to achieve the purpose of nerve repair and reconstruction.