Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (27): 5112-5114.doi: 10.3969/j.issn.1673-8225.2011.27.039

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Application of neural stem cell transplantation to brain injury therapy

Chen Lan, Li Mei   

  1. Department of Neurology, Guizhou Provincial People’s Hospital, Guiyang  550002, Guizhou Province, China
  • Received:2011-01-05 Revised:2011-04-09 Online:2011-07-02 Published:2011-07-02
  • Contact: Li Mei, Physician, Department of Neurology, Guizhou Provincial People’s Hospital, Guiyang 550002, Guizhou Province, China
  • About author:Chen Lan, Physician, Department of Neurology, Guizhou Provincial People’s Hospital, Guiyang 550002, Guizhou Province, China

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Abstract:

BACKGROUND: Neural stem cells (NSCs), which have the potential of differentiating into neurons and various glial cells, have been isolated from corpus striatum of adult rat brain.
OBJECTIVE: To summarize the effect and perspective of NSC transplantation in treatment of brain injury.
METHODS: EMbase (1980-01/2011-04), Medline (1966-01/2011-04), Chinese BioMedical Literature Database (1978/2011-04) and China National Knowledge Infrastructure were retrieved for relevant articles. The key words were “neural stem cells, brain injury, stroke, cerebral infarction”, and finally 12 articles were included.
RESULTS AND CONCLUSION: Results of animal study demonstrated that NSC transplantation could improve neural function and significantly decrease inflammatory reaction in the brain tissues. Silencing NgR gene, GDNF gene modification and combined transplantation of brain-derived neurotrophic factor could recover neural function to a greater degree. Clinical trials found that NSC transplantation could improve sequela after stroke to some degrees. These suggest that NSC transplantation obtained obvious outcomes, and could be futher utilized in clinic and for studying its clinical outcomes.

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