Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (27): 5104-5107.doi: 10.3969/j.issn.1673-8225.2011.27.037

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Research progress of adipose-derived stem cells inducing epidermal cells

Jiang Bo, Liao Yi, Tong Ting-hui   

  1. Department of Burn and Plastic Surgery, Luzhou Medical College, Luzhou  646000, Sichuan Province, China
  • Received:2011-01-21 Revised:2011-03-18 Online:2011-07-02 Published:2011-07-02
  • Contact: Liao Yi, Professor, Master’s supervisor, Department of Burn and Plastic Surgery, Luzhou Medical College, Luzhou 646000, Sichuan Province, China
  • About author:Jiang Bo★, Studying for master’s degree, Department of Burn and Plastic Surgery, Luzhou Medical College, Luzhou 646000, Sichuan Province, China jiangdabo1983@yahoo.cn

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Abstract:

BACKGROUND: Adipose-derived stem cells inducing epidermal cells are enabled to provide ideal treatment for refractory wounds healing.
OBJECTIVE: To analyze and sum up the research methods and ideas regarding the adipose derived stem cells in recent 10 years, in a broader attempt to summarize and explore the way how adipose derived stem cells induce epidermal cells.
METHODS: A computer-based retrieval of VIP Periodical Full-text Database and Wanfang database from January 2001 to October 2010 was performed, with the keywords of ADSCs and adipose derived stem cells in English and Chinese. Articles related with the adipose stem cells tissue engineering were included. Those of irrelevant purpose and repetitive content were ruled out. Finally 26 literatures were summarized.
RESULTS AND CONCLUSION: As a kind of seed cells available, adipose derived stem cells could directionally induce and differentiate to epidermal cells under some conditions, and improve the ability to induce differentiation and proliferation, thus achieving the goals of clinical usage. Adipose derived stem cells are characterized by abundant sources, easy gain, multi-directional differentiation potentials, good compatibility and small injury to patients, which make it surpass other mesenchymal stem cells. However, adipose derived stem cells manifest infinite proliferation like tumor cells in nonimmune transplanting receptors. The security after transplantation should be observed on suitable animal models in a long term before clinical trial. Moreover, there’s no secure and stable way to cultivate and induce adipose derived stem cells effectively, and how to maintain the quality of cells stable in the process of the abstracting and producing adipose derived stem cells remains further researches.

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