Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (27): 5100-5103.doi: 10.3969/j.issn.1673-8225.2011.27.036

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Platelet lysate on the proliferation and differentiation of umbilical cord mesenchymal stem cells

Sun Wei-xue1, Sun Kang1, Tian Shao-qi1, Xing Shi-chao2   

  1. 1Department of Joint Surgery, Affiliated Hospital, Qingdao University Medical College, Qingdao  266003, Shandong Province, China
    2Central Laboratory, Qingdao University Medical College, Qingdao  266000, Shandong Province, China
  • Received:2010-12-08 Revised:2011-01-31 Online:2011-07-02 Published:2011-07-02
  • Contact: Sun Kan, Doctor, Chief physician, Department of Joint Surgery, Affiliated Hospital, Qingdao University Medical College, Qingdao 266003, Shandong Province, China
  • About author:Sun Wei-xue★, Master, Department of Joint Surgery, Affiliated Hospital, Qingdao University Medical College, Qingdao 266003, Shandong Province, China weixuesun@gmail.com

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Abstract:

BACKGROUND: In recent years, umbilical cord mesenchymal stem cells (UCMSCs) are one of significant cells in stem cell biology. UCMSCs have a good prospect in the field of cell therapy. Platelet lysate has varying degrees of beneficial effect for proliferation and differentiation of stem cells. To a certain extent, it can replace or even is better than the serum in the culture medium.
OBJECTIVE: To summarize the studies regarding platelet lysate combined with UCMSCs.
METHODS: Literatures can be searched with keywords like umbilical cord, mesenchymal stem cells, platelet lysate, proliferation and differentiation in Chinese databases such as Wanfang and English databases such as PubMed. The biological characteristics and clinical practice of UCMSCs and platelet lysate were summarized. Studies regarding the effect of platelet lysate on the proliferation and differentiation of UCMSCs were included.
RESULTS AND CONCLUSION: Platelet lysate plays a positive role on the proliferation and differentiation of UCMSCs, thus indicating a significant role in the stem cell transplantation.

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