Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (27): 5096-5099.doi: 10.3969/j.issn.1673-8225.2011.27.035

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Roles of MicroRNA in regulating proliferation and differentiation of stem cells

Qi Shao-hua1, Wu Dong-cheng1, Li Dong-sheng2   

  1. 1Department of Biochemistry and Molecular Biology, Wuhan University Basic Medical College, Wuhan  430071, Hubei Province, China
    2Hubei Key Laboratory of Embryonic Stem Cells, Shiyan  442000, Hubei Province, China
  • Received:2011-01-26 Revised:2011-03-10 Online:2011-07-02 Published:2011-07-02
  • Contact: Wu Dong-cheng, Professor, Doctoral supervisor, Department of Biochemistry and Molecular Biology, Wuhan University Basic Medical College, Wuhan 430071, Hubei Province, China; bcdcwu@hotmail.com Correspondence to: Li Dong-sheng, Professor, Hubei Key Laboratory of Embryonic Stem Cells, Shiyan 442000, Hubei Province, China dsli@yymc.edu.cn
  • About author:Qi Shao-hua☆, Studying for doctoral degree, Department of Biochemistry and Molecular Biology, Wuhan University Basic Medical College, Wuhan 430071, Hubei Province, China qshhua@tom.com
  • Supported by:

    Science and Technology Fund by Wuhan University, No. 301275530*, 301275685*

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Abstract:

BACKGROUND: MicroRNAs (miRNAs) have an important role in regulating stem cell self-renewal and differentiation by repressing the translation of selected mRNAs in stem cells.
OBJECTIVE: To investigate the roles of miRNAs in regulating proliferation and differentiation of stem cells.
METHODS: The first author searched PubMed database, Elsevier database and Nature database from 2000 to 2010. Key words were “stem cell, embryonic stem cell (ESC), induced pluripotent stem cell (iPS cell), microRNA (miRNA)”. Duplicated articles were excluded. Finally, 39 articles were selected.
RESULTS AND CONCLUSION: MicroRNAs are specifically expressed in embryonic stem cells. MiRNAs play important roles in regulating stem cell’s proliferation and differentiation. MiRNAs modulate multiple stages and cell types of hemopoietic stem cell differentiation. MiRNAs also regulate the differentiation of neural stem cells, mesenchymal stem cells and skin stem cells. Embryonic stem cell-specific miRNAs promote the efficiency of somatic cell reprogramming.

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