Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (27): 5091-5095.doi: 10.3969/j.issn.1673-8225.2011.27.034

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Research development of Hedgehog signal pathway and proliferation and differentiation of related stem cells

Wang Li 1, Yang Zhi-yun2, Wang Xian-bo2   

  1. 1Beijing University of Chinese Medicine, Beijing  100029, China
    2Center for Integrated Traditional and Western Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing  100017, China
  • Received:2011-03-30 Revised:2011-05-19 Online:2011-07-02 Published:2011-07-02
  • Contact: Yang Zhi-yun, Doctor, Associate chief physician, Center for Integrated Traditional and Western Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing 100017, China yangzhiyun6@yahoo.com.cn Correspondence to: Wang Xian-bo, Doctor, Chief physician, Center for Integrated Traditional and Western Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing 100017, China wangxianbo638@163.com
  • About author:Wang Li★, Master, Beijing University of Chinese Medicine, Beijing 100029, China
  • Supported by:

    the General Program of National Natural Science Foundation of China, No. 30873423*

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Abstract:

BACKGROUND: Hedgehog protein is morphogen, and the signal pathway which is related to Hedgehog protein takes part in the embryogenesis and proliferation and differentiation of adult tissues.
OBJECTIVE: To review the proliferation and differentiation of stem cells related to Hedgehog signal pathway.
METHODS: The articles related to Hedgehog signaling pathway in CNKI database and PubMed Database from January 2000 to December 2010 were retrieved with the key words of “Hedgehog signaling pathway, cell proliferation, cell differentiation, signal pathway controlling”. The articles related to the function of Hedgehog signaling pathway to several kinds of stem cells and adult organs were selected. A total of 169 literatures were obtained from computer screen, and 27 documents of them were involved for summarization according to inclusion criteria.
RESULTS AND CONCLUSION: Stem cells with multiple differentiation potential developed into histiocytes with special biological function were regulated by stem cells or external, short-range or long-range signal. Intercellular information transfer plays an important role in the development and differentiation of cells. Hedgehog signal pathway can maintain the balance of cell proliferation, differentiation and apoptosis, and can regulate molecular difference among flanking cells, and play a crucial effect on cell differentiation.

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