Abstract:

BACKGROUND: Recently, with the development of tissue engineering, the substitutes of the vertebral body are various. Scholars focus on not only restoration of vertebral height and stability, but also long-term fusion effect, biocompatibility and mechanical properties.
OBJECTIVE: To analyze the histocompatibility and mechanical properties of artificial vertebral body.
METHODS: A retrieve of CNKI for articles about biocompatibility and mechanical properties of artificial vertebral body was performed using the keywords of “artificial vertebral body, compatibility, biomechanics”.
RESULTS AND CONCLUSION: The histocompatibility examination showed that nano-hydroxyapatite/polyamide 66 composites have similar composition and structure to human bone with good biocompatibility and osteogenic activity; can be biodegradable, and their degradation matches to osteogenic activity. The biomechanical studies demonstrated that nano-hydroxyapatite/polyamide 66 composites have good bioactivity, good axial compression load and excellent ability to branch out the intervertebral, meaning perfect mechanical properties. Bio-ceramic artificial vertebral body not only has good biocompatibility, but also plays a role in targeting location of vertebral tumors. After years of improvement, metal vertebral body can also meet the clinical requirements in biocompatibility. On the pros and cons of various types of artificial vertebral bodies, a large amount of studies and practices should be done, while in clinic, the selection of artificial vertebral body should be done according to the clinical need.