Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (26): 4829-4832.doi: 10.3969/j.issn.1673-8225.2011.26.020

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L4 vertebra stress relaxation and creep properties in ovariectomized rats with osteoporosis 

Zhang Qiao1, Zhang Zhong-jun2, Li Xin-ying1   

  1. 1China-Japan Union Hospital of Jilin University, Changchun  130031, Jilin Province, China
    2Department of Basic, Air Force Aviation University of Chinese PLA, Changchun  130022, Jilin Province, China
  • Received:2011-04-08 Revised:2011-05-30 Online:2011-06-25 Published:2011-06-25
  • About author:Zhang Qiao☆, Doctor, Attending physician, China-Japan Union Hospital of Jilin University, Changchun 130031, Jilin Province, China mahs@jlu.edu.cn

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Abstract:

BACKGROUND: For the prevention and treatment of osteoporosis, it is necessary to understand the relationships of the creep and stress relaxation of the spine with time in ovariectomized rats.
OBJECTIVE: To observe the osteoporosis effects on the viscoelastic properties of load-bearing bone of ovariectomized female rats.
METHODS: Forty-four Wistar female rats were divided into control and osteoporosis model groups. Rats in the model group were ovariectomized at 0 week. Stress relaxation trial with 1%/s strain rate and creep experiment with 0.01 MPa/s stress increasing rate. 100 data were collected within 7 200 seconds.
RESULTS AND CONCLUSION: The amount of stress relaxation and creep on L4 segment within 7 200 seconds was higher in the control group than the model group (P < 0.05). The stress relaxation curve changed in logarithmic manner, and the creep curve changed in exponential manner. The viscoelastic properties of ovariectomized rats with osteoporosis have changes.

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