Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (24): 4457-4460.doi: 10.3969/j.issn.1673-8225.2011.24.021

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Effect of ginsenoside Rd on collagen expression in liver fat-storing cells

Qiao Shi-wen1, Wang Ji-feng2, Huang Qin1, Zhu Zong-gui1, Zhang Zhi-gui1   

  1. 1Department of Anatomy, Leshan Vocational and Technical College Leshan  614000, Sichuan Province, China
    2Department of Anatomy, Luzhou Medical College, Luzhou  646000, Sichuan Province, China
  • Received:2010-12-11 Revised:2010-12-23 Online:2011-06-11 Published:2011-06-11
  • About author:Qiao Shi-wen, Associate professor, Department of Anatomy, Leshan Vocational and Technical College Leshan 614000, Sichuan Province, China ch19711109@126. com

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Abstract:

BACKGROUND: Collagens produced by liver fat-storing cells are the directly reasons for cirrhosis, thus, regulating capacity of fat-storing cells producing collagens can prevent cirrhosis.  
OBJECTIVE: To explore effect of ginsenoside Rd on expression of type Ⅰ and Ⅲ collagens in liver fat-storing cells in vitro.
METHODS: The liver fat-storing cells were cultured in vitro and interfered with ginsenoside Rd. The expression of type Ⅰ and Ⅲ collagens was detected by immunohistochemistry and immunofluorescent.
RESULTS AND CONCLUSION: Compared with the control group, the positive/negative-area and the absorbance of the experimental group were obviously decreased (P < 0.05), suggesting that ginsenoside Rd regulates the expression of type Ⅰ and Ⅲ collagens in liver fat-storing cells in vitro, which affects liver fat-storing cells producing collagens.

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