Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (24): 4387-4390.doi: 10.3969/j.issn.1673-8225.2011.24.005

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Preparation of rat femoral fracture model with an external fixator

Zhao Zhen-yu1, Shao Lin1, Liu Jian-yu1, Yang Da-ping2, Hao Chen-guang1, Zhao Hong-mei3, Liu Guo-feng2   

  1. 1Department of Bone Surgery, 2Department of Plastic Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin  150001, Heilongjiang Province, China; 3Department of Gynecology, Third Affiliated Hospital of Harbin Medical University, Harbin  150040, Heilongjiang Province, China
  • Received:2010-12-19 Revised:2011-02-20 Online:2011-06-11 Published:2011-06-11
  • Contact: Shao Lin, Professor, Chief physician, Department of Bone Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China linshao58@yeah.net
  • About author:Zhao Zhen-yu☆, Doctor, Attending physician, Department of Bone Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China zhenyuzhao78@ yeah.net
  • Supported by:

    the Science and Technology Program of Education Department of Heilongjiang Province, No 11511171*

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Abstract:

BACKGROUND: The external fixator has strong anti-rotation capability, thus, it not affect local blood supply or binding joints, which is suitable for preparing bone fracture models. 
OBJECTIVE: To design a new type animal model to study the fracture.
METHODS: Twenty-four right SD rats were performed right femoral osteotomy and fixed by a newly developed external fixator. Gross observation, imaging observation and histological method were used to observe the femoral positioning and healing of osteotomized bone ends.
RESULTS AND CONCLUSION: The external fixator maintained in the correct location of femur, with no signs of screw pull out, pinhole loosen, or fracture. Callus formation could be vague seen at 2 weeks after fixation. There were successive callus at 4 weeks, but the fracture end still clear. At 8 weeks after fixation, bone union could be found. The results demonstrated that external fixator utilized has sufficient stability for the management of fracture. This is a successful model of fracture in rats.

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