Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (24): 4379-4382.doi: 10.3969/j.issn.1673-8225.2011.24.003

Previous Articles     Next Articles

A loading device for study of bone mechanobiology

Xu Qiang1, Zhang Chun-qiu1, Guo Yong2, Wu Han3, Dong Xin4   

  1. 1School of Mechanical Engineering, Tianjin University of Technology, Tianjin  300384, China
    2Institute of Medical Equipment, Academy of Military Medical Science, Tianjin 300161, China
    3China-Japan Friendship Hospital, Jilin University, Changchun  130022, Jilin Province, China
    4College of Mechanical and Engineering, Jilin University, Changchun  130025, Jilin Province, China
  • Received:2010-12-02 Revised:2011-02-01 Online:2011-06-11 Published:2011-06-11
  • Contact: Zhang Chun-qiu, Doctor, Professor, Master's supervisor, School of Mechanical Engineering, Tianjin University of Technology, Tianjin 300384, China zhang_chunqiu@ 126.com
  • About author:Xu Qiang★, Studying for master’s degree, School of Mechanical Engineering, Tianjin University of Technology, Tianjin 300384, China sxhqxq@163.com
  • Supported by:

    the National Natural Science Foundation of China, No. 10832012*, 11072087*, 30772209*; the Natural Science Foundation of Jilin Province, No.20115023*

PDF

382

Abstract:

BACKGROUND: Articular cartilage cells respond to mechanical stimulation to maintain the morphological structure near cartilage of human body. A loading device can provide mechanical environment for studying mechanobiology. 
OBJECTIVE: To construct a dual-frequency loading device according to the bionic principle of tissue engineering.
METHODS: This mechanical environment was achieved by using dual-frequency loading method and implementing the coupling of low-frequency high-amplitude mechanical loading and high-frequency low-amplitude mechanical loading by controlling amplitude and frequency of cam and piezoelectric ceramics respectively, meanwhile, finite element method was used to make mechanics analysis on cartilage.
RESULTS AND CONCLUSION: In the light of the principle of simulation, a dual-frequency loading device has been developed for bone mechanobiology study. Under dual-frequency loading condition, mechanical loading on the surface layer of cartilage was largest, followed by the middle layer, smallest on the deep layer; when high-frequency of 10 and 20 Hz superpositioning low-frequency of 1 and 2 Hz, the cartilage show different mechanical responses; but the difference between two response was little. The construction of the mechanical environment of the device may be helpful to tissue engineering development and clinical applications; in addition, it will be tested with biological experiment in future.

CLC Number: