Abstract:

BACKGROUND: Titanium and titanium alloy are commonly used for medical biological materials, they have good biocompatibility, but lack of the ability of bone induction, the contact between titanium and bone tissue is a mechanical contact.
OBJECTIVE: To review the methods and efficacy of surface bioactivity modification for titanium and titanium alloy, and to provide references for further clinical application.
METHODS: A computer-based online search of literatures related to methods of surface bioactivity modification for titanium and titanium alloy was performed in PubMed database and CNKI database using the key words of “titanium, titanium alloy, coating, bioactivity, bone” in English and in Chinese respectively.
RESULTS AND CONCLUSION: The surface modification methods include plasma spraying, micro-arc oxidation, sol-gel and biomimetic methods. The surface coating of titanium and titanium alloy has been developed from a single coating to the composite coatings, gradient coatings and nano-gradient coatings. The joint use of two or three modification methods enhances the properties of the coating. After the surface modifications, the efficacy is investigated by simulating body fluid soaking, the culture of the osteoblasts, bone affinity fluorescein staining and radiology detection. Surface bioactivity modification for titanium and titanium alloy is a complex engineering, which requires to consider the bioactivity of surface coating and its bonding strength between the substrate, as well as the ability of bone induction. With the development of surface modification technology, the bioactivity and binding of surface coating for titanium and titanium alloy will be enhanced.