Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (20): 3653-3656.doi: 10.3969/j.issn.1673-8225.2011.20.011

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Establishment of a rabbit model of anterior residual alveolar ridge

Hu Yang1, Ma Ying2, He Hui-yu1   

  1. 1Department of Stomatology, First Affiliated Hospital of Xinjiang Medical University, Urumqi  830054, Xinjiang Uygur Autonomous Region, China
    2Department of Stomatology, Tianhe Central Hospital, Guangzhou  510630, Guangdong Province, China
  • Received:2010-11-02 Revised:2010-12-10 Online:2011-05-14 Published:2011-05-14
  • Contact: He Hui-yu, Doctor, Professor, Chief physician, Department of Stomatology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China hehuiyu2@sina.com
  • About author:Hu Yang★, Master, Physician, Department of Stomatology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China Joe98344@sina.cn
  • Supported by:

    the Tackle Key Program in Science and Technology of Xinjiang Uygur Autonomous Region, No. 200533118*; the Scientific Research Plan in Colleges and Universities of Xinjiang Uygur Autonomous Region, No. xj EDU2009I22*; the Science and Technology Items of Urumqi, No. Y09131002*

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Abstract:

BACKGROUND: A proper anterior residual alveolar ridge model can provide basis for the preservation and repair of residual alveolar ridge.
OBJECTIVE: To establish a rabbit animal model of anterior residual alveolar ridge.
METHODS: The eighteen New Zealand white rabbits were selected, both side of central incisors of 18 rabbits were extracted under the general anesthesia to prepare anterior residual alveolar ridge models. Rabbits were killed at 4, 8, and 12 weeks after operation. The length, width and height of residual alveolar after extraction were measured by Vernier caliper. The healing process of teeth extraction was observed by hematoxylin-eosin staining. The remodeling of bone trabecula in after extraction was examined by X-ray.
RESULTS AND CONCLUSION: The length, width and height of residual alveolar ridge were gradually decreased with time prolonged. Osteoblasts could be seen scattered in teeth extraction, new trabecular bone and vascular network was born. The deposition of new bone was continued in teeth extraction, the boundaries between new bone and the alveolar bone was not clear, and new bone and bone remodeling were happening in teeth extraction. Hematoxylin-eosin staining and X-ray photo showed that rabbit models of anterior residual alveolar ridge were successfully established.

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