Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (19): 3590-3593.doi: 10.3969/j.issn.1673-8225.2011.19.041

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Research progress on induced efficiency and methods of induced pluripotent stem cells

Zhang En-huan1, 2, Hu ZHi-xing2, 3, Li Ma-lin1, 2   

  1. 1Yunnan Key Laboratory of Pharmacology for Natural Products, 2Biomedical Engineering Research Center, 3Department of Pharmacology, Kunming Medical University, Kunming  650500, Yunnan Province, China
  • Received:2010-10-07 Revised:2011-01-26 Online:2011-05-07 Published:2011-05-07
  • Contact: Li Ma-lin, Doctor, Professor, Master’s supervisor, Yunnan Key Laboratory of Pharmacology for Natural Products, Biomedical Engineering Research Center, Kunming Medical University, Kunming 650500, Yunnan Province, China limalinb@vip.163.com
  • About author:Zhang En-huan★, Studying for master’s degree, Yunnan Key Laboratory of Pharmacology for Natural Products, Biomedical Engineering Research Center, Kunming Medical University, Kunming 650500, Yunnan Province, China 419437487@qq.com
  • Supported by:

    the Special Funds of "Eleventh Five-Year" National Major Science and Technology for Major New Drugs Oriented, No. 2008ZX09202-005*; National Natural Science Foundation of China, No. 30860357*

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Abstract:

BACKGROUND: Induced pluripotent stem cells (iPS) is a type of pluripotent stem cell artificially derived from human or animal adult somatic cells which were transfected with certain pluripotency genes. At present, the researches on induced pluripotent stem cells have made great progresses.
OBJECTIVE: To review the research progress in the conversion efficiency and optimization of induction methods in iPS cells.
METHODS: A computer-based online search of Medline database (http://www.ncbi.nlm.nih.gov/Pubmed) from January 2006 to July 2010 was performed with the key words of “induced pluripotent stem cells” in English. The literatures were limited to English language. Totally 1 831 literatures were retrieved, 57 documents of which were involved for summarization.
RESULTS AND CONCLUSION: The researches on iPS cells have a great and far-reaching impact on life science, which makes it become a hot issue in stem cell field. And some rapid progresses have been made in iPS research such as cellular reprogramming, the improvement of efficiency of induction, optimization of the induction methods, the enlargement of cell origin and differentiation of functional cells. These researches would lay a foundation for clinical cell replacement therapy of iPS.

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