Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (17): 3217-3220.doi: 10.3969/j.issn.1673-8225.2011.17.042

Previous Articles     Next Articles

Mechanism of lipid metabolism in alcohol-induced and steroid-induced osteonecrosis of the femoral head

Shi Shao-hui1, Li Zi-rong2, Sun Wei2, Wang Bai-liang2, Pan Lin3, Wang Ran-dong1   

  1. 1Department of Orthopedics, Aviation Industry Central Hospital, Beijing  100012, China
    2Center for Bone Necrosis and Joint Reconstruction, China-Japan Friendship Hospital,  Beijing  100029, China
    3Institution of Clinical Medicine, China-Japan Friendship Hospital, Beijing  100012, China
  • Received:2010-10-22 Revised:2011-01-21 Online:2011-04-23 Published:2011-04-23
  • About author:Shi Shao-hui☆, Doctor, Attending physician, Department of Orthopedics, Aviation Industry Central Hospital, Beijing 100012, China ssh_snake@yahoo. com.cn

PDF

519

Abstract:

BACKGROUND: There are various theories about the pathogenesis of non-traumatic femoral head necrosis, and lipid metabolism is just a hypothesis, but how to participate in the pathogenesis of osteonecrosis is still unclear.
OBJECTIVE: To observe the change of lipid and histomorphometric index in patients with alcohol- and steroid-induced osteonecrosis of the femoral head, to explore the mechanism of lipid metabolism in non-traumatic osteonecrosis of the femoral head.
METHODS: 162 ARCO Ⅱ-Ⅳ cases of osteonecrosis of the femoral head were selected in the experiment, including 57 cases of alcohol-induced osteonecrosis, 63 cases of steroid-induced osteonecrosis, and 42 cases of traumatic osteonecrosis. Blood tests for lipids were made for all patients, including triglyceride (TG), low density lipoprotein (LDL), etc. Parts of the femoral head after hip replacement were selected for the study, namely 12 cases in each group. The femoral heads were cut along the middle coronal plane, their weight-bearing and non-weight-bearing areas were processed by routine HE staining, then to analysis the area of the bone marrow, fat cell density, fat cell diameter and fat cell size in each group.
RESULTS AND CONCLUSION: Increased rate of TG in alcohol-induced patients was significantly higher than those in steroid-induced osteonecrosis and , traumatic osteonecrosis. (P < 0.05); The decreased rate of LDL in alcohol-induced osteonecrosis was significantly higher than those in steroid-induced osteonecrosis and traumatic osteonecrosis (P < 0.05). Compared to the patients with steroid-induced osteonecrosis of the femoral head, the area and diameter of fat cell were larger in alcohol-induced patients, but the blood area was smaller, and there was significant difference between the two groups. Whether in weight-bearing area or in non-weight-bearing area, there was insignificant difference with histomorphometric indexes between alcohol-induced and steroid-induced patients, including blood area, fat cell density, diameter and size of fat cells. The changes of lipid metabolism play an important regulatory role in the late period of alcohol-induced osteonecrosis of the femoral head, but do not play a regulatory role in the late period of steroid-induced osteonecrosis of the femoral head.

CLC Number: