Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (7): 1285-1289.doi: 10.3969/j.issn.1673-8225.2011.07.033

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Diversity between genetic adaptation to hypoxia and non-adaptation in plateau residents

Liu Zhong1, Li Wen-hua2   

  1. 1Medical College of Tibet University, Lhasa  850002, Tibet Autonomous Region, China
    2Department of Medical Sciences, Tibet Nationalities Institute, Xianyang   712082, Shaanxi Province, China
  • Received:2010-09-04 Revised:2010-12-29 Online:2011-02-12 Published:2011-02-12
  • Contact: Li Wen-hua, Associate professor, Department of Medical Sciences, Tibet Nationalities Institute, Xianyang 712082, Shaanxi Province, China xzmylwh@163.com
  • About author:Liu Zhong, Associate professor, Medical College of Tibet University, Lhasa 850002, Tibet, China Li Wen-hua, Associate professor, Department of Medical Sciences, Tibet Nationalities Institute, Xianyang 712082, Shaanxi Province, China xzmylwh@163.com Liu Zhong and Li Wen-hua contributed equally to this paper
  • Supported by:

    the Science and Technology Foundation of Tibet Autonomous Region, No.2010*

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Abstract:

BACKGROUND: The studies concerning heredity and environment to plateau adaptation are few. What degree does plateau adaptation regulated by genetic gene remains unclear thought there must be different gene changes in plateau residents from non-adaptation population.  
OBJECTIVE: To found the DNA polymorphism sites of plateau residents different from non-adaptation population by analyzing hemoglobin, enzyme, receptor, polypeptide and transcription factor in recent 5 years. 
METHODS: PubMed and Wanfang Databases were searched using key words of “hypoxia adaptation to high altitude, genetics, DNA polymorphisms”. A total of 40 documents were analyzed after depleting irrespective and repetitive papers.
RESULTS AND CONCLUSION: Genetics studies concerning hypoxia adaptation focused on physiology and pathophysiological processes during hypoxia adaptation, including bioactive substance related to altitude disease, energy metabolism under hypoxia conditions, and a series of protein genes, such as HB related gene, endothelium nitric oxide synthase gene, hypoxia inducible factor-1α, glutathione S-transferase gene, rennin-angiotensin-aldosterone gene, glutathione S-transferase gene, pulmonary surfactant-associated protein genes, were play an important role in plateau residents to plateau adaptation.

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