Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (7): 1290-1294.doi: 10.3969/j.issn.1673-8225.2011.07.034

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Yinxingdamo injection versus Dansen injection for treatment of acute cerebral infarction: A Meta analysis 

Li Yin1, Lü Jian-wei1, Chen Lin2   

  1. 1Department of Pharmacy, Liuzhou Hospital of Traditional Chinese Medicine, Liuzhou  545001, Guangxi Zhuang Autonomous Region, China
    2Graduate in 2006, Changchun University of Chinese Medicine, Changchun  130117, Jilin Province, China
  • Received:2010-08-19 Revised:2010-09-16 Online:2011-02-12 Published:2011-02-12
  • About author:Li Yin★, Master, traditional Chinese pharmacist-in-charge, Department of Pharmacy, Liuzhou Hospital of Traditional Chinese Medicine, Liuzhou 545001, Guangxi Zhuang Autonomous Region, China xye666662010@live.cn

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Abstract:

BACKGROUND: Dansen injection and Yinxingdamo injection are common used in the treatment of acute cerebral infarction. Many articles have confirmed that the outcomes of Yinxingdamo injection are superior to Dansen injection. However, the deficient number of cases impacts the credibility of the articles. 
OBJECTIVE: To analyze the clinical efficacy of Yinxingdamo injection and Dansen injection in treatment of acute cerebral infarction and to make an objective evaluation.
METHODS: A thorough literature search of random controlled test about Yinxingdamo injection and Dansen injection in treatment of acute cerebral infarction was performed in Chinese hospital library and Wanfang Database published from January 1998 to February 2010. Inclusive criteria: according to the revised acute cerebral infarction diagnosis standard of the fourth national cerebrovascular disease academic conference held in 1995, patients have been diagnosed to be acute cerebral infarction by head CT or the MRI. Exclusive criteria: Documents lack of foundation treatment, the methods of diagnosis and treatment involved other factors which had influence to the clinical efficacy, or drug combination had significant influence to the result. The Meta-analyze was performed by ReviewManager 5.0. Clinical assessment index including total effective rate, changes of hemorheology and neurologic impairment scores.
RESULTS AND CONCLUSION: Fifteen literatures including 1 614 cases were subsumed. Compared with Dansen injection, the total clinical effective rate of Yinxingdamo injection was more higher (OR=3.70, 95%CI: 2.81-4.88, P < 0.001); the changes of blood plasma viscosity of Yinxingdamo injection were more greater, the blood plasma viscosity was (SMD=-1.01, 95%CI: -1.69 to-0.32, P < 0.001) and the red blood cell accumulation index (SMD=-0.25, 95%CI: -0.3 to -0.14, P < 0.01); the recovery of neurologic impairment of Yinxingdamo injection was stronger (SMD=-0.73, 95%CI: -0.88 to -0.59, P < 0.001). It can be initially proved that Yinxingdamo injection has superior efficacy on acute cerebral infarction to Dansen injection. 

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