Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (7): 1264-1268.doi: 10.3969/j.issn.1673-8225.2011.07.028

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Cellular mechanism of biological activity of propolis 

Li Yuan1, Ding Zhong-juan2   

  1. 1Kunming Medical University, Kunming  650031, Yunnan Province, China
    2Department of Prosthodontics, the Affiliated Stomatology Hospital of Kunming Medical College, Kunming 650031, Yunnan Province, China
  • Received:2010-10-14 Revised:2010-11-25 Online:2011-02-12 Published:2011-02-12
  • Contact: Ding Zhong-juan, Doctor, Chief physician, Master’s supervisor, Doctoral supervisor, Department of Prosthodontics, the Affiliated Stomatology Hospital of Kunming Medical College, Kunming 650031, Yunnan Province, China dingzhongjuan@sina.com
  • About author:Li Yuan★, Studying for master’s degree, Kunming Medical University, Kunming 650031, Yunnan Province, China Liyuan-bing@163. com
  • Supported by:

    the National Natural Science Foundation of China, No. 30960424*

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Abstract:

BACKGROUND: Propolis, a natural product collected by honey bees, possesses variety biological effects, such as anti-tumor, antioxidant, anti-inflammatory, immunomodulatory, treating diabetes mellitus, as well as hepatoprotective effect. The cellular mechanism of biological activity of propolis are research focuses.
OBJECTIVE: To analyze pharmacological mechanisms of propolis on cells from a cellular level.
METHODS: A computer-based online search was conducted in China Academic Journals Database and PubMed with the key words of “propolis, antitumor, antioxidant, antiinflammatory, immunoregulation, diabetes mellitus, hepatocyte”, both in English and Chinese from 1977 to 2010 to retrieve articles on pharmacological mechanisms of propolis on cells. Literatures of irrelevant purpose and repetitive content were excluded. 
RESULTS AND CONCLUSION: Totally 47 literatrue were included. The pharmacological mechanisms of propolis on cells were summarized. As a natural drug, Propolis can protect and repair cells, regulate cell viability and influence cytokine secretion from pathways of antioxidant, eliminate free radical, or regulate inflammatory factor.

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