Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (7): 1269-1272.doi: 10.3969/j.issn.1673-8225.2011.07.029

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Transgenic animal models of osteoarthritis

Cao Bin, Li Yan-lin, Li Xiao-lin, Ma Ke, Xu Peng, Yang Guang, Wang Guo-liang   

  1. Department of Orthopaedics, the First Affiliated Hospital of Kunming Medical College, Kunming  650032, Yunnan Province, China
  • Received:2010-09-02 Revised:2010-10-08 Online:2011-02-12 Published:2011-02-12
  • Contact: Li Yan-lin, Doctor, Professor, Doctoral supervisor, Department of Orthopaedics, the First Affiliated Hospital of Kunming Medical College, Kunming 650032, Yunnan Province, China Yanlinli1969@yahoo.com.cn
  • About author:Cao Bin★, Studying for master’s degree, Physician, Department of Orthopaedics, the First Affiliated Hospital of Kunming Medical College, Kunming 650032, Yunnan Province, China caobin5959@sina.com
  • Supported by:

    the National Natural Science Foundation of China, No. 30860286*

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Abstract:

BACKGROUND: In recent years, transgenic animal osteoarthritis models are presented with development of transgenic technology, which indicated that, different gene deletions and mutations may lead to osteoarthritis. This provides new plan of medicine screening and treats for osteoarthritis.
OBJECTIVE: To summary the construction and relevant mechanisms with osteoarthritis of transgenic animal models, and to provide theoretical basis for prevention and treatment of osteoarthritis.
METHODS: The first author retrieved PubMed database for English articles published from 1995 to 2010. The key words were “transgenic animal models, osteoarthritis”. Simultaneously, CNKI database was retrieved for relevant Chinese articles published from 2000 to 2010. A total of 158 articles were obtained, and finally 25 articles were included.
RESULTS AND CONCLUSION: Osteoarthritis of transgenic animal models has obvious advantages in the study of the initial mechanism, biochemical changes in articular cartilage, prevention and treatment of osteoarthritis, which eliminate the influence by the surgical trauma and inflammation to the cartilage and the biochemical metabolism of synovial of osteoarthritis model, also relieve the pain of animals. This provides new plans for medicine screening and treats for osteoarthritis.

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