Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (2): 261-264.doi: 10.3969/j.issn.1673-8225.2011.02.017

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Expression of monocyte ehemoattraetant protein-1 and bone morphogenic protein-7 in pathologic scars  

Li Yong-tao1, 2, Wang Xi-mei1, Liu Lin-bo1, Zhang Jian-wen1, Yuan De-pin1, 2   

  1. 1Department of Plastic Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou  450052, Henan Province, China
    2Open Laboratory of Phytopathology, Key Discipline of Clinical Medical Sciences, Institution of Henan Province High Learning, Zhengzhou  450052, Henan Province, China
  • Received:2010-09-08 Revised:2010-12-09 Online:2011-01-08 Published:2011-01-08
  • Contact: Wang Xi-mei, Doctor, Chief physician, Master’s supervisor, Department of Plastic Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China wangximei228@ gmail.com
  • About author:Li Yong-tao★, Studying for Master’s degree, Department of Plastic Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China; Open Laboratory of Phytopathology, Key Discipline of Clinical Medical Sciences, Institution of Henan Province High Learning, Zhengzhou 450052, Henan Province, China liyongtao830123@ 163.com

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Abstract:

BACKGROUND: Monocyte ehemoattraetant protein-1 (MCP-1) has been shown chemotaxis and activation effect on mononuclear/macrophage. As a newly found negative-regulatory factor, bone morphogenic protein-7 (BMP-7) has aroused increasing attention in the treatment of tissue fibrosis. However, the effects of MCP-1 and BMP-7 on tissue fibrosis during pathologic scars remain poorly understood. 
OBJECTIVE: To investigate the expression of MCP-1 and BMP-7 in pathologic scars.
METHODS: SP immunohistochemical method was used to detect the expressions of MCP-1 and BMP-7 in 25 cases of keloid, 30 cases of hypertrophic scars, 24 cases of non-pathologic scar and 20 cases of normal skin tissues. All specimens obtained from plastic surgery patients that had no skin disease, connective disease, infectious disease, malignant tumor and other important viscera diseases, no radiation therapy, laser therapy and immunotherapy before surgery in the First Affiliated Hospital of Zhengzhou University. Meanwhile, the scar tissues were taken from the patients who were diagnosed clearly by the clinic, and they were confirmed by pathology.
RESULTS AND CONCLUSION: The positive rates of MCP-1 in keloid group was higher than that of the hypertrophic scar and normal skin groups (P < 0.05), but the positive rates of BMP-7 was decreased (P < 0.05). There was a negative correlation between MCP-1 and BMP-7 expression in pathologic scars (keloid and hypertrophic scars) (r=-0.639, P < 0.01). Results demonstrated that MCP-1 expression up regulated and BMP-7 expression down regulated during development of pathologic scars.

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