Abstract:

BACKGROUND: Bioabsorbable and durable drug-eluting stents are widely used in coronary atherosclerotic heart disease intervention, due to the variations in the stent structure, drugs and drug carrier, several studies on the efficacy and safety of the two stents is not entirely consistent.
OBJECTIVE: To compare the efficacy and safety of bioabsorbable drug-eluting stents with durable drug-eluting stents in treating coronary atherosclerotic heart disease patients undergoing percutaneous coronary intervention.
METHODS: A computer-aided search of MEDLINE (January 1966 to July 2010), EMBASE (January 1980 to July 2010), Cochrane library (July 2010), Chinese Biomedical Databases (January 1990 to July 2010) was conducted to collected the control studies related with bioabsorbable drug-eluting stents versus durable drug-eluting stents for treatment of coronary heart disease. The methodological quality of included studies was assessed according to Cochrane handbook 5.1.2. Statistical analysis was performed using RevMan 5.0 software.
RESULTS AND CONCLUSIONS: Data from 10 controlled trials were included with a total of 4 391 cases, including 2 429 cases undergoing bioabsorbable drug-eluting stents and 1 962 cases undergoing durable drug-eluting stents. Meta analysis indicated no significance differences in incidence of major cardiac events, in-stent restenosis, target lesion revascularization, cardiac death, recurrent myocardial infarction and in-stent thrombosis between two groups within 6-12 months after the stent implantation. But the in-stent late loss was significantly lower in the bioabsorbable drug-eluting stent group compared with the durable drug-eluting stent group (P < 0.05). Bioabsorbable drug-eluting stents and durable drug-eluting stents are effective and safe in treating coronary atherosclerotic heart disease. Bioabsorbable drug-eluting stents are not inferior to durable stents and have a definite advantage in suppressing the neointimal hyperplasia.