Abstract:

BACKGROUND: Osteopontin is a phosphorylation exists in extracellular matrix, which plays an important role in bone formation and remodeling. The effects of osteopontin on anti-inflammatory, and process of injury repair and vascular remodeling has aroused an increasing attention.
OBJECTIVE: To explore the role of osteopontin in the development of vascular remodeling.
METHODS: A computer-based online search was performed to search articles relevant to effect of osteopontin on vascular proliferative diseases, and the research progress of osteopontin on vascular remodeling was analyzed.
RESULTS AND CONCLUSION: Osteopontin can specifically promote adhesion and migration of vascular smooth muscle cells stimulated by biological factors through RGD sequences in different pathway. Osteopontin can also regulate vascular remodeling by inhibiting vessel calcification. Osteopontin can be considered as a target for precaution and therapy of vascular proliferative diseases.